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Can a single injection ease pain and help swallowing after robotic throat surgery?

NCT ID NCT05862792

Symptom relief Sponsor: Geisinger Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether injecting a long-lasting local anesthetic called EXPAREL (liposomal bupivacaine) into the surgical wound can improve pain control and swallowing function in 80 adults undergoing robotic surgery for throat cancer. Participants will be compared to those who do not receive the injection. The goal is to see if this approach reduces pain and opioid use while helping patients swallow better after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
liposomal bupivacaine (EXPAREL)
What this could lead to
If it works, this could provide better pain relief and faster return to normal swallowing after robotic throat cancer surgery, reducing the need for opioid painkillers.
What could go wrong
This is a small, early-stage study (80 people) comparing two standard-care options. The anesthetic may not significantly improve pain or swallowing, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2023

Expected to finish

Jan 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients undergoing TORS

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients, greater than or equal to 18 years of age; Patients of all genders; Patients undergoing transoral robotic surgery; Patient who are able and willing to give consent Exclusion Criteria: * Patients with an allergy to Bupivacaine or other amide anesthetics; Patients with a carnitine deficiency

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Conditions

The condition(s) this trial relates to.

Deglutition Disorders oropharyngeal carcinoma oropharynx cancer oropharynx squamous cell carcinoma Pain, Postoperative squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dysphagia, oropharyngeal Oropharyngeal cancer Post operative pain Transoral robotic surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Geisinger Medical Center

    RECRUITING

    Danville, Pennsylvania, 17821, United States

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