NON-HODGKIN LYMPHOMA

This study tests a vaccine called Triplex to prevent cytomegalovirus (CMV) infection in adults who have received a stem cell transplant. CMV is usually harmless but can be life-threatening for people with weakened immune systems. The vaccine uses harmless virus pieces to train th…

This study tests a vaccine designed to protect people who have had a stem cell transplant from a common virus called CMV. The virus can cause serious illness in those with weakened immune systems. The vaccine uses a safe, weakened virus to teach the body to fight CMV, with the go…

This study offers ongoing treatment with the drug CC-122 (Avadomide) to 12 people with Non-Hodgkin Lymphoma who have already been taking it for over 5 years in earlier trials and are still seeing benefits. The main goal is to monitor long-term safety and serious side effects. Par…

This study is testing a drug called acalabrutinib, alone or together with other drugs (rituximab and lenalidomide), in people with B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. The goal is to see how safe these combinations are and whether they can…

This early-phase trial tests whether the drug duvelisib can help CAR T-cells persist longer in people with non-Hodgkin lymphoma or acute lymphocytic leukemia. About 42 adults who have already received a standard CAR T-cell therapy will take duvelisib pills daily. The main goal is…

This early-phase trial tests whether adding special immune cells called veto cells to a stem cell transplant can help donor cells grow in the patient without causing severe graft-versus-host disease (GVHD). The study includes 16 people with various blood cancers or bone marrow fa…

This early-phase study tests SC291, a type of immunotherapy made from donor cells, in people with certain blood cancers (non-Hodgkin lymphoma or chronic lymphocytic leukemia) that have come back or not responded to other treatments. The goal is to check if it is safe and to get a…

This early-phase study tests a new cell therapy called huCART19-IL18 for people with CD19-positive blood cancers (like some leukemias and lymphomas) that have relapsed or not responded to standard treatments. The therapy involves modifying a patient's own immune cells to better t…

This early-phase study tests whether specially trained immune cells from healthy donors can safely fight Epstein-Barr virus (EBV)-related cancers and severe viral diseases. About 38 patients with EBV-positive lymphomas, nasopharyngeal carcinoma, or other EBV-driven conditions wil…

This early-stage study tests a new drug called GNC-038, a quad-specific antibody designed to attack cancer cells in multiple ways. It is for people with certain blood cancers (non-Hodgkin's lymphoma or acute lymphoblastic leukemia) that have come back or not responded to standard…

This study tests a combination of an immunotherapy drug (pembrolizumab) and low-dose radiation for people with non-Hodgkin lymphoma that has come back or not responded to prior treatments. Six participants will receive the drug plus radiation to one or more tumor sites. The goal …

This study tests a new treatment for people with Hodgkin or non-Hodgkin lymphoma that has returned or not gone away. Researchers take a patient's own immune cells, train them in a lab to recognize five cancer-specific proteins, and give them back as an infusion. Some adults also …

This study planned to test two drugs—golcadomide and nivolumab—together in adults with non-Hodgkin lymphoma that did not respond or came back after CAR-T cell therapy. The goal was to find a safe dose and see if the combination could shrink tumors. However, the study was withdraw…

This early-phase study tests an experimental drug called DS-3201b in about 100 adults with non-Hodgkin lymphoma whose cancer has come back or is not responding to current treatments. The main goals are to find a safe dose and see how the drug works in the body. The study also che…

This phase 3 study tests whether a combination of two targeted drugs (mosunetuzumab and polatuzumab vedotin) works better than a standard chemotherapy regimen for people with aggressive B-cell non-Hodgkin lymphoma that has returned or not responded to prior therapy. About 208 adu…

This early-stage study tests a mix of six drugs (called ViPOR-P) in adults with B-cell lymphomas that came back or didn't respond to prior treatment. The goal is to see if the combination is safe and can shrink tumors. About 34 participants will take pills and receive infusions o…

This early-phase study tests whether giving radiation therapy before standard CAR T cell treatment is safe and practical for people with B-cell lymphoma that has come back or not responded to prior treatments. About 20 participants will receive split-course bridging radiation to …

This early-stage study tests a new treatment for people with non-Hodgkin lymphoma that has come back or not responded to at least two prior therapies. The approach uses a patient's own T cells, which are modified in a lab to recognize and attack cancer cells, then infused back in…

This early-phase study tests whether vaccinating stem cell donors against cytomegalovirus (CMV) can prevent the virus from causing problems in blood cancer patients after a transplant. About 34 donor-recipient pairs are taking part. The vaccine is given to the donor before stem c…

This study tests whether adding acupuncture to standard pain care can reduce the need for strong opioid painkillers in people with multiple myeloma, Hodgkin disease, or non-Hodgkin lymphoma who are getting high-dose chemotherapy. About 299 adults will be randomly assigned to rece…

This study follows 144 blood cancer patients undergoing stem cell transplants to see how muscle function changes and whether it predicts complications like infections, relapse, or survival. Researchers will measure muscle mass and track medical events over time. The goal is to un…

This study follows about 150 people who previously received Caribou cell therapy for blood cancers like lymphoma or leukemia. Researchers will check for long-term side effects and overall survival for up to 15 years after treatment. No new treatment is given—this is just observat…