NON-ALCOHOLIC STEATOHEPATITIS

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by about 70%, can help people with obesity and a serious liver condition called MASH. Participants will be randomly assigned to receive either ESG plus …

This study looks at how the liver responds to food in people with non-alcoholic fatty liver disease (NAFLD) and whether the drug semaglutide can reduce liver fat and damage. About 84 adults with NAFLD and healthy volunteers will participate. Researchers will measure liver fat, en…

This study looks at whether combining blood tests, genetic markers, and gut bacteria analysis can find liver scarring (fibrosis) earlier than current methods. Researchers will study 1,200 adults referred to a liver clinic. The goal is to catch serious liver disease sooner and red…

This study aims to find new blood-based tests that can accurately detect liver scarring (fibrosis) in people with non-alcoholic fatty liver disease, without needing a painful liver biopsy. Researchers will collect blood samples and ultrasound data from 575 adults with suspected l…

This study collects tissue and blood samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, like cell clusters and mouse tumors, to better understand these diseases and test new treatments. The goal is to impro…

This study aims to find out how many people have non-alcoholic fatty liver disease (NAFLD) and its more serious form, NASH. Researchers will use advanced MRI scans to diagnose the condition in 800 adults from Olmsted County, Minnesota. Participants will be followed over time to t…

This study looks at whether a special ultrasound technique, called endoscopic ultrasound shear wave elastography (EUS-SWE), can better detect liver scarring in people with obesity and fatty liver disease. Standard non-invasive tests are often less accurate in this group. Research…