NON-ALCOHOLIC STEATOHEPATITIS

This study looks at how the liver responds to eating in people with non-alcoholic fatty liver disease (NAFLD) and whether the drug semaglutide can reduce liver fat and damage. About 84 adults with NAFLD and healthy volunteers will take part. Participants with NAFLD will receive w…

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study aims to improve early diagnosis of liver fibrosis (scarring) by combining standard blood tests with new markers, genetic analysis, and gut bacteria profiles. Researchers will enroll 1,200 adults referred to a liver clinic. The goal is to identify advanced fibrosis soon…

This study aims to find new blood-based markers that can accurately detect liver scarring (fibrosis) in people with fatty liver disease. Currently, the best way to check for scarring is a liver biopsy, which is painful and risky. Researchers will collect blood samples from 575 ad…

This study looks at whether a special ultrasound technique, called endoscopic ultrasound shear wave elastography (EUS-SWE), can better detect liver scarring in people with obesity and fatty liver disease. Standard non-invasive tests are often less accurate in this group. Research…

This study aims to find out how common non-alcoholic fatty liver disease (NAFLD) and its more serious form, NASH, are in Olmsted County. Researchers will follow 800 adults over time to improve diagnosis and track long-term health issues like liver damage, heart problems, and canc…

This study collects tissue and blood samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, such as cell clusters and mouse models, to test new treatments in the future. Participants do not receive any experime…