NON-ALCOHOLIC FATTY LIVER DISEASE

This study tests whether a smartphone app can help Chinese adults with non-alcoholic fatty liver disease (NAFLD) lose weight over 12 months. Weight loss is currently the only proven way to improve this condition, which affects over 40% of adults in Hong Kong. The app provides gui…

This study tests an experimental drug called MN-001 in 40 adults with fatty liver disease, type 2 diabetes, and high triglycerides. Participants take either the drug or a placebo daily for 24 weeks. The main goals are to see if the drug reduces liver fat and lowers blood fat leve…

This study tests an experimental drug, GSK4532990, to see if it can improve liver scarring and inflammation in people with nonalcoholic steatohepatitis (NASH) who already have advanced fibrosis. About 284 adults will receive either the drug or a placebo for up to 52 weeks. The go…

This study tests an experimental drug called efinopegdutide in 80 adults with liver scarring (cirrhosis) caused by a type of fatty liver disease (MASH). The goal is to see if the drug can lower liver fat, inflammation, and scarring over about 7 months. Participants will receive e…

This phase 2 study tests whether semaglutide, a once-weekly injection, can help preserve insulin-producing cells and reduce liver fat in 60 obese youth with prediabetes or early type 2 diabetes and fatty liver disease. Participants receive semaglutide or placebo for 6 months, wit…

This study was designed to test a new device that uses sound and heat to measure fat in the liver. It would compare the device's accuracy to standard MRI scans in adults with or suspected of having non-alcoholic fatty liver disease. The goal was to see if this simpler method coul…

This study tests whether a low-sugar diet can prevent non-alcoholic fatty liver disease (NAFLD) in Hispanic children aged 6 to 9 who are at higher risk. Over 2 years, 103 kids will either follow the diet or eat as usual. Researchers will measure liver fat and inflammation to see …

This study looks at whether exercising once a week or three times a week is better for reducing liver fat in adults with non-alcoholic fatty liver disease (NAFLD) and central obesity. 300 participants will follow exercise programs that match World Health Organization guidelines. …

This pilot study aimed to see if a special MRI scan called field-cycling imaging could detect different stages of non-alcoholic fatty liver disease (NAFLD), from early fat buildup to more serious scarring. The study planned to include adults with NAFLD who could safely have an MR…

This study aims to find out how common non-alcoholic fatty liver disease (NAFLD) is among adults in Flanders, Belgium. Researchers will screen 10,000 people visiting their general practitioner using simple, non-invasive methods like quality-of-life questionnaires. The goal is to …

This study looks at whether teens and young adults with Polycystic Ovary Syndrome (PCOS) have more fat in their liver than those without PCOS. Researchers will use advanced scans and tests to measure liver fat, insulin resistance, and cholesterol in 80 participants aged 14-25. Th…

This study looks at how amino acids (building blocks of protein) trigger the liver to release certain hormones, and why this process may be different in people with fatty liver disease. Researchers will give amino acid infusions to 30 healthy volunteers and patients with fatty li…

This study looks at why people with HIV are more likely to develop fatty liver disease. Researchers think changes in gut bacteria might be a cause. They will test if taking probiotics and fiber can improve liver health in 63 participants.

This large study will follow 100,000 Chinese families from before pregnancy until children reach age 14. Researchers want to learn how parents' health, lifestyle, and environmental exposures before and during pregnancy affect pregnancy outcomes, child development, and long-term h…

This study looks at why storing fat in and around organs like the liver affects some people's health more than others. Researchers will measure insulin sensitivity and inflammation in 144 lean and obese adults. The goal is to better understand these differences to help develop fu…