MYELODYSPLASTIC SYNDROMES

This study tested whether adding an experimental drug (VIC-1911) to standard medications can prevent graft-versus-host disease (GVHD) and relapse in adults with blood cancers like leukemia or lymphoma who receive a stem cell transplant. Sixteen participants were enrolled. The goa…

This study tested a drug called palifermin in 34 adults with blood cancers who received stem cells from an unrelated donor. The goal was to see if palifermin could reduce severe graft-versus-host disease (GVHD), a common complication where donor cells attack the patient's body. P…

This early-stage study tested a new drug called JNJ-64619178 in 114 people with advanced cancers, including lymphoma and solid tumors. The main goal was to find the safest dose and check for side effects. The drug works by blocking a protein that helps cancer cells grow.

This early-phase trial tested a drug called ONC-201 in 20 people with acute myeloid leukemia or myelodysplastic syndrome who had recently received a stem cell transplant. The goal was to see if taking ONC-201 weekly for a year could help prevent the cancer from coming back. The s…

This early-phase study tested a new type of stem cell transplant (microtransplantation) in 25 people with acute myeloid leukemia or myelodysplastic syndromes who were too old or sick for a standard transplant. Unlike standard transplants, this approach used partially matched fami…

This study tested a less intense stem cell transplant for people with various blood cancers who are older or have other health issues. It used a half-matched family donor (like a parent or sibling) and a milder chemo and radiation preparation. The goal was to see how many patient…

This early-phase study tested an oral drug called NTX-301 in 22 adults with blood cancers (MDS, AML, or CMML) that had not responded to prior treatment. The main goal was to check safety and find the right dose. Researchers also looked for signs that the drug could control the di…

This early-stage study tested a new drug called JNJ-74856665 in 153 people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The main goal was to find safe doses and check for side effects. The drug works by blocking a key enzyme cancer cells need to grow. Thi…

This study looked at a new way to do bone marrow transplants for people with blood cancers like leukemia and lymphoma who don't have a perfectly matched donor. Instead of using a standard drug after transplant, doctors tested a different drug called bendamustine to see if it coul…

This early-phase study tested a combination of two cancer drugs, bortezomib and clofarabine, in 28 adults with advanced solid tumors, lymphomas, or myelodysplastic syndromes that had stopped responding to standard treatments. The main goal was to find a safe dose and see how well…

This study looked at whether giving the antibiotic levofloxacin can prevent serious infections in people with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) who are being treated with azacitidine. Infections are a major risk for these patients. The study enrolled…

This study tested a new treatment for people with myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (AML) whose first therapy stopped working. The treatment uses specially selected immune cells from a donor to fight the cancer without causing long-term side effec…

This study tested the drug dasatinib in 68 adults with several blood and bone marrow disorders, including certain leukemias, myelofibrosis, and mastocytosis. The goal was to see if dasatinib could help control these diseases and to check its safety. Results focused on how many pa…

This study tested different low doses and schedules of the drug ASTX727 in 160 adults with lower-risk myelodysplastic syndromes (MDS), a type of blood cancer. The goal was to find a dose that improves blood cell counts and reduces the need for blood transfusions while being safe.…

This study tested a new way to help people with blood cancers like leukemia and lymphoma get hospice care earlier. Normally, patients delay hospice because they need blood transfusions for symptom relief, but hospices can't afford to provide them. The study paid for transfusions …

This study looked back at medical records of 418 adults with lower-risk myelodysplastic syndromes (MDS) who had not previously received certain anemia treatments. Researchers examined how doctors prescribed luspatercept, how long patients stayed on it, and what outcomes occurred,…

This study followed 349 adults with myelodysplastic syndromes (MDS), a bone marrow disorder that raises the risk of leukemia. Researchers used DNA testing to find gene changes and see how they affected survival and treatment response. The goal was to better understand the disease…

This study looked at over 1,700 people with blood cancers or disorders who needed a bone marrow transplant. Researchers compared two strategies: first searching for a matched unrelated donor and then an alternative if needed, versus going straight to an alternative donor. The goa…

This study tested whether a telehealth program could help older adults (60+) with acute myeloid leukemia or myelodysplastic syndrome plan their future medical care. Researchers worked with 36 patients, their caregivers, and doctors to see if the program was easy to use and practi…