MYELODYSPLASTIC SYNDROMES

This study tested whether adding the experimental drug MBG453 to standard chemotherapy (azacitidine) helps people with high-risk myelodysplastic syndrome (MDS) or a related leukemia (CMML-2) live longer. About 530 adults who could not have intensive chemo or a stem cell transplan…

This study tested a drug called MBG453 in 10 people with lower-risk myelodysplastic syndromes (MDS), a bone marrow disorder. The goal was to see if the drug could improve blood cell counts and reduce the need for blood transfusions. The trial was terminated early, so results are …

This study tested two oral drugs, eltanexor and Inqovi, in adults with high-risk myelodysplastic syndromes (MDS) that had not responded to earlier treatment. The goal was to find a safe dose and see if the combination could improve blood cell counts or lead to remission. However,…

This early-phase study aimed to find safe doses of drug combinations for adults with lower-risk myelodysplastic syndrome (MDS), a blood disorder. Researchers enrolled 33 participants to check for side effects and how well the drugs were tolerated. The study was terminated early, …

This study tested a treatment called TCB008 for people with acute myeloid leukemia (AML) that came back or didn't respond to standard therapy. TCB008 uses donated immune cells (gamma-delta T cells) grown in a lab to attack cancer cells. The trial aimed to see if these cells could…

This early-phase study tested whether giving a special type of cell (interferon gamma-primed mesenchymal stromal cells) around the time of a bone marrow transplant is safe and feasible for people with blood cancers. Only 4 participants were enrolled before the study was ended ear…

This early-phase study tested a new drug called DSP107 combined with standard chemotherapy drugs (azacitidine with or without venetoclax) in adults with acute myeloid leukemia, myelodysplastic syndrome, or chronic myelomonocytic leukemia that had returned or not responded to up t…

This study tested a new drug called BMS-986253 for people with myelodysplastic syndromes (MDS), a bone marrow disorder. The goal was to see if the drug was safe and could help control the disease. However, the trial was stopped early after only 2 participants joined, so no clear …

This early-stage trial tested a new drug called gentulizumab in 58 people with advanced acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that had not responded to other treatments. The drug aims to help the immune system attack cancer cells by blocking a protein cal…

This study tested an experimental drug (INCB000928) for anemia in people with myelodysplastic syndromes (MDS) or multiple myeloma who needed blood transfusions or had anemia symptoms. The goal was to check safety and find the right dose. The study was stopped early, and only 22 p…

This early-stage study tested a new drug called SAR443579 in adults and children with blood cancers like acute myeloid leukemia and others that had come back or not responded to treatment. The goal was to find a safe dose and see if the drug could shrink the cancer. The study was…

This study tested an experimental drug called MBG453 added to standard chemotherapy for people with intermediate to very high-risk myelodysplastic syndrome (MDS) who could not have a stem cell transplant. The goal was to see if the combination could improve remission rates and de…

This early-stage study tested a new drug called CC-95251, alone or with other cancer drugs, in 56 people with acute myeloid leukemia or myelodysplastic syndromes that had come back or not responded to treatment. The main goal was to check safety and find the right dose. The study…

This early-stage study tested a new drug called INKmune in people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The goal was to see if it was safe and to find the best dose. Only 2 people took part before the study was stopped early.

This early-phase trial tested a new drug called SL-172154, given with standard chemotherapy drugs (azacitidine with or without venetoclax), in adults with higher-risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The study aimed to find a safe dose and check for…

This early-stage study aimed to see if an oral (pill) form of the chemotherapy drug cladribine works similarly to the standard IV (intravenous) version in people with certain blood cancers like leukemia. Only 3 people took part before the study was stopped early. The main goal wa…