MORBID OBESITY

This study is testing whether a higher dose of the blood thinner bemiparin is better than the standard dose at preventing dangerous blood clots in severely obese patients after surgery. The trial will enroll 2,400 participants with a BMI of 40 or higher who are having general, gy…

This study compares two types of gastric bypass surgery for people with severe obesity. One method uses fixed lengths for the rerouted intestine, while the other customizes the lengths based on each person's total small bowel size. The goal is to see if the customized approach le…

This study looks at whether continuing GLP-1 agonist drugs (like Ozempic or Wegovy) after weight-loss surgery helps people lose more weight and control blood sugar better than stopping them. About 150 adults with severe obesity will be randomly assigned to either keep taking the …

This study tests a tailored version of SADI-S weight-loss surgery that adjusts the bypass length to each patient's anatomy. It aims to improve weight loss and reduce vitamin deficiencies. The study includes 40 adults with obesity, either as a first surgery or after a failed sleev…

This study looks at genetic and chemical markers in fat tissue from 500 people with severe obesity who are having weight-loss surgery. Researchers want to compare fat from people with and without diabetes or other health problems to better understand why some obese people are hea…

This study follows 300 people having weight-loss (metabolic) surgery to see how their gut bacteria change and how that affects heart health and diabetes. Researchers collect stool, blood, and tissue samples before and up to 3 years after surgery. The goal is to learn which gut mi…

This study aims to understand why children with ROHHAD syndrome gain weight so quickly. Researchers will compare the genes and metabolism of affected children to their healthy siblings. The goal is to find the root causes of this rare condition, which may lead to better treatment…

This observational study looks at 50 adults with severe obesity who are scheduled for either sleeve gastrectomy or gastric bypass. Researchers will check stool samples before surgery and 6 months after to see if simple tests can reveal differences in digestion, gut inflammation, …

This study follows 1000 people who had weight-loss (bariatric) surgery 5 years ago to see how well they maintain weight loss. Researchers want to learn why some succeed long-term while others do not, and which surgery type works best. The goal is to help future patients choose th…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. …