MEDULLOBLASTOMA

This study looks at whether giving lower doses of radiation and chemotherapy to children with a specific, less-aggressive type of brain tumor (WNT medulloblastoma) can still cure the cancer while causing fewer long-term problems like learning issues or hormone imbalances. About 4…

This early-stage study tests a flavored, drinkable chemotherapy called VAL-413 (Orotecan) for children and young adults (ages 1-30) whose solid tumors have come back. The drug is given by mouth along with another chemo, temozolomide, for 5 days. The main goal is to find the safes…

This study tests a cancer vaccine called SurVaxM in 35 children whose brain tumors have come back or are hard to treat. The vaccine teaches the immune system to find and destroy tumor cells. The goal is to see if it is safe and helps control the disease.

This early-stage study tested a drug called APX005M in 32 children whose brain tumors had come back or were hard to treat, including a type called DIPG. The goal was to find a safe dose and see how the body reacts. The drug works by helping the immune system attack the tumor cell…

This study is for children under 10 with high-risk medulloblastoma or other central nervous system embryonal tumors. It compares two chemotherapy approaches after initial treatment: one round of very high-dose chemo with stem cell rescue versus three rounds. The goal is to see if…

This early-phase trial tests whether specially engineered immune cells (IL13Rα2-CAR T cells) can safely target and destroy brain tumor cells that have spread to the lining of the brain and spinal cord. Ten adults with glioblastoma, ependymoma, or medulloblastoma will receive thes…

This study tests a drug called indoximod, which aims to help the immune system fight brain tumors. It is for children aged 3 to 21 with certain types of progressive brain cancer or a newly diagnosed brainstem tumor (DIPG). Participants receive indoximod alongside standard chemoth…

This study tests a personalized approach to treating medulloblastoma, a type of brain cancer, in children and young adults. Participants receive surgery, radiation, and chemotherapy, but the doses and drugs are tailored based on the tumor's molecular type and how much cancer rema…

This early-stage study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The cells are…

This study is testing a new type of PET/CT scan that uses a special tracer (68Ga-DOTATOC) to find neuroendocrine tumors and other related cancers. The goal is to see if this scan is safer and more sensitive than current imaging methods. About 800 people with known or suspected tu…

This study looks at whether a special PET scan using a natural amino acid called methionine can help doctors see tumors in children and young adults with cancer. About 500 participants will get the scan to check if it can find tumors at diagnosis and tell the difference between a…

This study looks at how radiation therapy affects the brain in children with medulloblastoma, a type of brain tumor. Researchers use special PET scans to measure inflammation in different brain areas over time. The goal is to understand how radiation causes long-term changes in t…