MEDULLOBLASTOMA

This early-phase trial tests a new cell therapy called B7-H3 CAR T cells for children and young adults whose brain tumors have come back or are growing despite standard treatment. The therapy uses a patient's own immune cells, modified to recognize and attack a protein (B7-H3) fo…

This study tests a new approach called pharmacoscopy, which uses a lab test on a patient's tumor sample to find which drugs might work best for them. It involves 40 adults with brain tumors like glioblastoma that have not responded to standard treatments. The goal is to see if th…

This study looks at a new way to give radiation to children with brain tumors that need whole-brain and whole-spine treatment. The technique, called vertebral body-sparing proton therapy, aims to protect the front of the spine bones to preserve bone marrow and growth. Researchers…

This study tests a combination of a vaccine (PEP-CMV) and an immunotherapy drug (nivolumab) in children and young adults with certain aggressive brain tumors. The goal is to see if this approach is safe and helps the immune system fight the cancer. About 68 participants will be e…

This study tests a thyroid hormone (liothyronine) combined with standard chemotherapy drugs for children and young adults whose medulloblastoma has returned or worsened. The goal is to see if the combination is safe and can control the disease. About 69 participants will be enrol…

This study looks at two standard treatments for a type of brain tumor called low-risk medulloblastoma in children under 5. The goal is to see which treatment better protects thinking and learning skills 2.5 years after diagnosis. About 96 children will take part, and researchers …

This study is testing a mobile app called my.naviGATE for teens and young adults (ages 15-24) who have finished cancer treatment. The app provides personalized education, peer support, and tracks how patients are doing. Researchers want to see if using the app helps patients feel…