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New flavored chemo drink offers hope for kids with hard-to-treat cancers

NCT ID NCT04337177

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 32 times

Summary

This early-stage study tests a flavored, drinkable chemotherapy called VAL-413 (Orotecan) for children and young adults (ages 1-30) whose solid tumors have come back. The drug is given by mouth along with another chemo, temozolomide, for 5 days. The main goal is to find the safest dose and see how the body processes the medicine. About 20 participants will be enrolled.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Atrium Health Levine Children's Hospital - Carolinas Medical Center

    Charlotte, North Carolina, 28204, United States

  • Children's Healthcare of Atlanta - Arthur M. Blank Hospital

    Atlanta, Georgia, 30329, United States

  • Children's National Research Institute - Children's National Hospital

    Washington D.C., District of Columbia, 20010, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229-3039, United States

  • Duke University Children's Hospital and Health Center

    Durham, North Carolina, 27710, United States

  • Indiana University School of Medicine, Riley Hospital for Children

    Indianapolis, Indiana, 46202, United States

  • Phoenix Children's Hospital

    Phoenix, Arizona, 85016, United States

  • Sarah Cannon Research Institute, Pediatric Hematology & Oncology

    Nashville, Tennessee, 37203, United States

  • UCSF, Mission Bay - Benioff Children's Hospital

    San Francisco, California, 94143, United States

  • University of North Carolina at Chapel Hill - North Carolina Cancer Hospital

    Chapel Hill, North Carolina, 27514, United States

  • Washington University - St. Louis

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.