MAJOR DEPRESSIVE EPISODE
Clinical trials for MAJOR DEPRESSIVE EPISODE explained in plain language.
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Home brain zaps tested to keep depression away
Disease control Recruiting nowThis study tests whether a gentle, at-home brain stimulation device (tDCS) can help people with depression maintain their improvement after successful hospital treatments like rTMS, ECT, or esketamine. Thirty adults who have already improved will use the device for 30 minutes, 5 …
Matched conditions: MAJOR DEPRESSIVE EPISODE
Phase: NA • Sponsor: Technical University of Munich • Aim: Disease control
Last updated May 22, 2026 13:55 UTC
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New tool aims to stop depression before it starts
Prevention Recruiting nowThis study tests whether a coach-guided, personalized risk communication tool can help prevent major depression in adults at high risk. Researchers will recruit 1,000 participants across Canada and follow them for 12 months. The tool provides personalized risk information and evi…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Phase: NA • Sponsor: Dalhousie University • Aim: Prevention
Last updated May 26, 2026 06:19 UTC
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Ketamine boost for severe depression: faster relief on the horizon?
Symptom relief Recruiting nowThis study tests whether adding a single dose of ketamine to the antidepressant venlafaxine can speed up symptom relief in people hospitalized for severe depression. About 60 adults with major depression will receive either ketamine or a placebo alongside venlafaxine. The goal is…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Phase: PHASE3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated May 26, 2026 06:14 UTC
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Sound waves for sadness: can ultrasound zap depression?
Symptom relief Recruiting nowThis study is testing a new way to treat depression using gentle ultrasound waves aimed at specific brain areas. 30 adults with hard-to-treat depression will get personalized, non-invasive brain stimulation while researchers monitor mood and brain activity with MRI. The goal is t…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Phase: PHASE1, PHASE2 • Sponsor: Brian Mickey • Aim: Symptom relief
Last updated May 26, 2026 06:11 UTC
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Can brain scans explain Post-COVID depression?
Knowledge-focused Recruiting nowThis study looks at why some people develop depression after a mild or moderate COVID-19 infection. Researchers will use brain scans to compare brain activity in 90 adults who have new depression after COVID-19. The goal is to better understand the brain changes involved, not to …
Matched conditions: MAJOR DEPRESSIVE EPISODE
Sponsor: Centre for Addiction and Mental Health • Aim: Knowledge-focused
Last updated May 26, 2026 06:19 UTC
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Can brain scans predict the best depression treatment?
Knowledge-focused Recruiting nowThis study follows 1,000 adults with hard-to-treat depression or OCD who receive advanced treatments like brain stimulation or ketamine. Researchers will collect data from brain scans, cognitive tests, and voice recordings to find markers that predict which treatment works best f…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Sponsor: Mark Niciu • Aim: Knowledge-focused
Last updated May 26, 2026 06:18 UTC