Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Brain wave patterns and inflammation: a clue to ECT's effectiveness in older adults?

NCT ID NCT07740694

Knowledge-focused Sponsor: Istanbul University - Cerrahpasa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study investigates whether brain wave patterns (measured by EEG) and inflammatory markers in the blood can help predict how well older adults with depression or bipolar disorder respond to electroconvulsive therapy (ECT). Researchers will compare EEG recordings and blood samples taken before and after ECT treatment, looking for changes that correlate with clinical improvement. The goal is to better understand how ECT works in the aging brain and potentially identify biomarkers that could guide personalized treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Electroconvulsive therapy (ECT) using the Thymatron System IV device
What this could lead to
If successful, this could help predict which older adults with depression or bipolar disorder will benefit most from ECT, and may guide more personalized treatment decisions.
What could go wrong
This is an observational study, so it won't directly test a new treatment. The findings may not apply to all patients, and the relationship between biomarkers and ECT response could be complex and not definitive.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 62 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with Major Depressive Disorder or Bipolar Disorder Major Depressive Episode who were suggested ECT clinically and 55 years of age or older, and sociodemographically compatible healthy controls who are 55 years of age or older and do not have a known neuropsychiatric diagnosis at the time of research.

Ages

55 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patient Group * Age ≥55 years. * Diagnosis of Major Depressive Disorder or Bipolar Disorder, current major depressive episode, according to DSM-5 criteria. * Clinical indication for electroconvulsive therapy (ECT). * Ability to provide written informed consent. * Willingness to participate in the study. Healthy Control Group: * Age ≥55 years. * No current psychiatric disorder. * No known neurological disorder. * Good general physical health. * No current use of medications known to affect EEG activity or inflammatory biomarkers significantly. * Ability to provide written informed consent. * Willingness to participate in the study. Exclusion Criteria: * Primary neurological disorders (e.g., dementia or traumatic brain injury). * Schizophrenia or other psychotic disorders. * Intracranial space-occupying lesions. * Increased intracranial pressure. * Myocardial infarction within the previous 3 months. * Cerebrovascular disease within the previous month. * Unstable cerebral aneurysm. * Pheochromocytoma. * Electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS) within the previous month. * Cognitive impairment severe enough to prevent adequate cooperation during EEG recording. * Current alcohol or substance use disorder. * Active infectious disease. * Uncontrolled autoimmune or chronic inflammatory disorders. Participants with stable disease who had received the same maintenance treatment within the previous 3 months were eligible for inclusion.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Bipolar affective disorder are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

bipolar depression bipolar disorder catatonia Depressive Disorder, Treatment-Resistant major affective disorder 6 major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bipolar affective disorder Bipolar anhedonic depression Bipolar depression Bipolar depression depressed phase Catatonia Major depression moderate Major depression severe Major depression with comorbid anxiety symptoms Major depression with panic attacks Major depression with psychotic features Major depressive episode

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • İstanbul University- Cerrahpasa, Cerrahpasa Medicine Faculty, Psychiatry Department

    RECRUITING

    Istanbul, Bakırköy, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.