Major depressive episode
Clinical trials for Major depressive episode explained in plain language.
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Can a targeted magnetic pulse rewire the depressed brain?
Disease control OngoingThis trial is testing two different forms of repetitive transcranial magnetic stimulation (rTMS) to see which might better ease depression and anxiety in people whose symptoms haven't improved with standard treatments. About 100 adults with treatment-resistant depression will rec…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Sponsor: University of British Columbia • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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Ketamine vs. ECT: which stops suicidal thoughts faster?
Disease control By invitation onlyThis study compares two treatments—electroconvulsive therapy (ECT) and intravenous ketamine—for quickly reversing acute suicidal depression in 1,500 adults aged 18 to 90. Participants are randomly assigned to receive either ECT or ketamine twice a week for up to four weeks. The m…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Phase 4 • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Which pill works best for bipolar depression? huge study aims to find out
Disease control OngoingThis large study compares four FDA-approved medications for bipolar depression to see which one helps people feel better. Over 2,700 adults with bipolar I or II disorder and current depression will be randomly assigned to one of the drugs. The goal is to find which treatment lead…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Phase 4 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Sound waves to lift mood? new study tests ultrasound for depression
Symptom relief OngoingThis study tests a new, non-invasive brain stimulation method using low-intensity ultrasound waves aimed at specific brain areas linked to depression. Researchers will personalize the treatment for each of the 30 participants based on their brain scans. The goal is to see if this…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Phase 1/2 • Sponsor: Brian Mickey • Aim: Symptom relief
Last updated Sep 10, 2026 00:00 UTC
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Bipolar depression study scrapped before it began
Knowledge-focused CancelledThis study was designed to explore how cariprazine (Vraylar) might help people with bipolar depression by looking at its effect on a specific brain receptor (D3 dopamine). Participants would have taken cariprazine for six weeks and undergone PET scans to see how the drug works in…
Matched conditions: MAJOR DEPRESSIVE EPISODE
Phase 4 • Sponsor: New York State Psychiatric Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC