LUNG CARCINOMA

This early-phase study tests the safety and best dose of the drug veliparib when given with standard chemotherapy (carboplatin and paclitaxel) in adults with advanced solid tumors that also have liver or kidney dysfunction. The goal is to find out how the body processes the drugs…

This early-stage study tests a new radioactive tracer called 18F-αvβ6-BP to see if it can safely and effectively highlight cancers in the breast, colon, lung, pancreas, and related metastases. About 27 adults with these cancers will receive the tracer and undergo PET scans. The g…

This study tests whether metformin, a safe and widely used diabetes drug, can lower the risk of lung cancer in overweight or obese former smokers at high risk for the disease. About 50 participants will take metformin extended release for 6 months, and researchers will measure ch…

This early-phase trial tests a MUC1 peptide vaccine in 50 current or former smokers at high risk for lung cancer. The goal is to see if the vaccine is safe and can train the immune system to recognize and attack precancerous cells. Researchers hope this approach may slow or stop …

This study looks at whether a yoga program can improve physical performance, quality of life, and reduce symptoms like fatigue and distress in cancer patients undergoing radiation therapy, as well as their partners. About 600 patients with lung, head and neck, or esophageal cance…

This study tests whether adding care coordination services—like tracking results, sending reminders, and helping patients schedule follow-ups—can improve how often people get the right follow-up care after lung cancer screening. About 6,772 current or former smokers aged 50-80 wi…

This study looks at whether using suction during a lung biopsy (EBUS-TBNA) helps get better tissue samples from people with suspected lung cancer that has spread to lymph nodes. About 50 adults will take part. The goal is to see if suction increases the amount of tissue collected…

This study looks at what happens when older smokers (ages 50-80) who are at high risk for lung cancer switch from regular cigarettes to e-cigarettes. Researchers will track how many cigarettes they smoke and measure health markers like inflammation in their blood. The goal is to …

This study looks at whether a 12-week virtual exercise program, combined with group counseling, can change the bacteria in the gut and reduce inflammation in smokers at high risk for lung cancer. About 65 people aged 50-77 who smoke or used to smoke will take part. The goal is to…

This study tests a web-based education tool called HOPE-Genomics that teaches cancer patients about their genetic test results. About 465 adults with lung, breast, colorectal, pancreatic, ovarian, or prostate cancer are taking part. The goal is to see if the tool helps patients r…

This study tests a drug called canakinumab in 41 former smokers at high risk for lung cancer. The drug blocks a protein involved in inflammation, which may help reduce cancer growth. Researchers will measure changes in inflammation markers from samples of the mouth, nose, and blo…

This study tests whether analyzing the genes in a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced or hard-to-treat cancers (solid tumors, lymphoma, or myeloma) had their tumors genetically screened. Those with specific genetic c…

This study looked at whether routine screening tests for prostate, lung, colorectal, and ovarian cancers can lower the number of deaths from these diseases. Over 154,000 people aged 55-74 took part. Researchers compared those who got screened with those who received usual care to…

This study was designed to look at how community cancer clinics test for biomarkers in common cancers like lung, breast, and colorectal cancer. The goal was to find out if testing is fast and accurate, and to spot any differences in how tests are done. However, the study was with…