LUMBAR SPINAL STENOSIS

This study is testing a metal plate (Minuteman G5) that is already approved for use, to see how well it helps people with long-term low back pain caused by spine conditions like spinal stenosis. About 150 adults will get the plate and bone graft, then be followed for a year to me…

This study looks at whether avoiding opioids during lumbar spine surgery can still control pain while reducing side effects like nausea and constipation. About 75 adults having elective back surgery will be split into three groups based on the anesthesia they receive: opioid-free…

This study compares a new, flexible endoscope technique (LUSE-TLIF) to the current standard minimally invasive surgery (MIS-TLIF) for treating single-level lumbar spinal stenosis, a common cause of back and leg pain. About 276 adults aged 40-70 with confirmed stenosis and instabi…

This study compares two surgeries for a condition called lumbar spinal stenosis, where the spine narrows and causes pain or numbness. One surgery removes bone to relieve pressure, while the other also adds screws to stabilize the spine. The goal is to see which approach gives bet…

This study looks at whether using local anesthesia (where you are awake but numb) is as good as or better than general anesthesia (being fully asleep) for a common back surgery called lumbar decompression. About 100 adults aged 40-95 with lumbar spinal stenosis will take part. Th…

This study looks at a procedure called MILD that uses a small tool to relieve pressure on nerves in the lower back. Researchers will track 8,000 Medicare patients to see if MILD leads to fewer complications and less need for more surgery compared to other treatments. The goal is …

This study tests a simple, non-surgical program for older veterans with lumbar spinal stenosis, a common cause of back and leg pain. The program includes using a modified rolling walker and changing sleep positions to relieve symptoms. Researchers will track improvements in walki…

This study tests whether a modified version of the muscle relaxant metaxalone can reduce sudden low back and leg pain caused by spinal stenosis and sciatica. About 50 adults aged 18 to 80 with new back or leg pain will take either the active drug or a placebo for 7 days. Research…

This study tests if placing a steroid directly on the spine during back surgery helps reduce pain and the need for opioid painkillers afterward. About 150 adults having a 1-2 level lumbar laminectomy will be randomly assigned to receive the steroid or not. Researchers will track …

This study tests whether a specific nerve block (erector spinae plane block) can reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults undergoing certain types of back surgery will receive either the nerve block or a placebo. The g…

This study compares two surgical treatments for single-level lumbar spinal stenosis: decompression alone versus decompression with fusion. Researchers want to find out if adding fusion improves long-term results or if decompression alone is enough. About 86 adults aged 45-75 with…

This study looks at tissue removed during back surgery to find people who may have a heart condition called transthyretin cardiac amyloidosis (ATTR-CA). The goal is to catch the disease early, when treatments work best. Researchers will test spine samples from 1,663 older adults …

This study looks at whether the natural pulsation of the spinal cord lining (dura) is linked to pain and disability in people with lumbar spinal stenosis, a condition where the spinal canal narrows. Researchers will measure dural pulsation on MRI and compare it to patients' repor…