LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Clinical trials for LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA explained in plain language.
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New chemo sequence aims to shrink pancreatic tumors enough for surgery
Disease control Recruiting nowThis study is for people with pancreatic cancer that is either borderline or locally advanced, meaning it has not spread far but is hard to remove surgically. Researchers want to see if giving two different chemotherapy combinations one after the other can shrink the tumor enough…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated May 26, 2026 11:49 UTC
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New gene therapy takes on tough pancreatic cancer
Disease control Recruiting nowThis early-stage trial tests a new cell-based gene therapy called RR001 given after chemotherapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The study aims to check safety and find the best dose in about 9 participants. It is not a cure, …
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: EIR Biotherapies s.r.l. • Aim: Disease control
Last updated May 26, 2026 11:49 UTC
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New combo attack on pancreatic cancer shows promise in early trial
Disease control Recruiting nowThis study is for people with locally advanced pancreatic cancer that cannot be removed by surgery. It tests a two-step chemotherapy plan (first Gemcitabine/Nab-paclitaxel, then FOLFIRINOX) followed by precise MRI-guided radiation. The goal is to stop the cancer from growing and …
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle • Aim: Disease control
Last updated May 26, 2026 11:46 UTC
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New chemo combo tested against tough pancreatic cancer
Disease control Recruiting nowThis study tests two different chemotherapy combinations in people with advanced pancreatic cancer that has spread or cannot be removed by surgery. About 52 adults will be randomly assigned to receive either NALIRIFOX or a modified gemcitabine-based regimen. The goal is to see wh…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Medical University of South Carolina • Aim: Disease control
Last updated May 26, 2026 11:44 UTC
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Sound waves boost chemo against tough pancreatic tumors
Disease control Recruiting nowThis study tests a new approach called Acoustic Cluster Therapy (ACT) combined with standard chemotherapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. ACT uses ultrasound to help chemotherapy drugs penetrate deeper into tumors. The goal is…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: EXACT Therapeutics AS • Aim: Disease control
Last updated May 26, 2026 11:44 UTC
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New drug aims to stop deadly clots in pancreatic cancer patients
Disease control Recruiting nowThis study tests a drug called Kinisoquin™ to see if it can prevent dangerous blood clots in people with advanced pancreatic cancer. About 480 adults with metastatic or locally advanced pancreatic cancer who are starting chemotherapy will receive either Kinisoquin™ or a placebo. …
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE3 • Sponsor: Quercis Pharma AG • Aim: Disease control
Last updated May 26, 2026 11:37 UTC
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New dual-action approach targets hard-to-treat pancreatic cancer
Disease control Recruiting nowThis early-phase study tests a two-part system: one radioactive substance helps doctors see pancreatic cancer tumors on scans, and another delivers targeted radiation therapy. The goal is to check safety and find the right dose in 30 adults with advanced pancreatic cancer that ha…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: EARLY_PHASE1 • Sponsor: University of California, Davis • Aim: Disease control
Last updated May 26, 2026 11:36 UTC
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New radiation boost shows promise for tough pancreatic cancer
Disease control Recruiting nowThis study tests whether a high-dose radiation boost after standard chemotherapy can help people with locally advanced pancreatic cancer live longer and feel better. About 43 participants whose tumors shrank or stayed stable after chemo will receive targeted radiation. Researcher…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated May 26, 2026 11:35 UTC
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Light and immune combo takes on tough pancreatic cancer
Disease control Recruiting nowThis study tests a new approach for people with pancreatic cancer that cannot be surgically removed. It combines a light-activated drug (verteporfin) with an immunotherapy (pembrolizumab) and standard chemotherapy. The goal is to see if this combination can shrink tumors better t…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 26, 2026 11:35 UTC
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New drug-radiation combo targets tough pancreatic cancer
Disease control Recruiting nowThis study tests a drug called M3814 (Peposertib) combined with a special type of radiation for people with locally advanced pancreatic cancer that has spread to nearby tissues. The goal is to find the safest dose and see if the combo helps stop the cancer from growing longer tha…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 11:34 UTC
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Promising new combo aims to slow tough pancreatic cancer
Disease control Recruiting nowThis study tests whether adding a targeted drug called panitumumab to standard chemotherapy can help people with a specific type of advanced pancreatic cancer (KRAS wild-type) live longer. About 94 adults whose cancer has spread or can't be removed will receive either chemo alone…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE3 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated May 22, 2026 14:05 UTC
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New hope for tough pancreatic cancers: PTM-101 trial opens
Disease control Recruiting nowThis early-phase study tests a new drug called PTM-101 given alongside standard chemotherapy for people with pancreatic cancer that is borderline resectable or locally advanced (not yet spread to distant organs). The goal is to see if adding PTM-101 is safe and can shrink tumors …
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1 • Sponsor: PanTher Therapeutics • Aim: Disease control
Last updated May 22, 2026 13:52 UTC
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New combo targets tough pancreatic tumors
Disease control Recruiting nowThis early-stage study tests a drug called XER-001 given through a tube into the gut, combined with precise radiation, for people with locally advanced pancreatic cancer that cannot be removed by surgery. The main goals are to find the safest dose and see if the treatment can con…
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Xerient Pharma • Aim: Disease control
Last updated May 22, 2026 13:50 UTC
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Electric fields and radiation team up against tough pancreas cancer
Disease control Recruiting nowThis study tests whether adding Tumor Treating Fields (TTF) to targeted radiation therapy can slow tumor growth in people with locally advanced pancreas cancer. Participants receive radiation for five days and use a wearable TTF device for at least 18 hours daily. The goal is to …
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Phase: NA • Sponsor: Baptist Health South Florida • Aim: Disease control
Last updated May 19, 2026 11:47 UTC
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New study explores surgery hope for inoperable pancreatic cancer
Knowledge-focused Recruiting nowThis study looks at whether surgery can be an option for people with locally advanced pancreatic cancer after chemotherapy shrinks the tumor. Researchers will track 150 patients at expert centers to see if surgery improves survival and quality of life. The goal is to learn which …
Matched conditions: LOCALLY ADVANCED PANCREATIC ADENOCARCINOMA
Sponsor: Azienda Ospedaliera di Padova • Aim: Knowledge-focused
Last updated May 22, 2026 14:02 UTC