Sound waves boost chemo attack on tough pancreatic tumors
NCT ID NCT06850623
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding Acoustic Cluster Therapy (ACT) to standard chemotherapy can shrink inoperable pancreatic tumors. About 25 adults with locally advanced pancreatic cancer will receive both treatments. The goal is to see if the combination improves response rates and is safe.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
About 25 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Jun 2025
- Expected to finish
-
Jul 2027
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Not deemed suitable for primary curative surgery and have radiographic and pathological disease consistent with inoperable LAPC or borderline resectable pancreatic cancer. * Suitable to receive treatment with mFOLFIRINOX according to the Investigator's assessment. Exclusion Criteria: • Any prior anti-cancer treatment for pancreatic cancer (e.g. chemotherapy, surgery, radiation). Palliative bypass procedure and bile duct stenting are allowed.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Locally advanced pancreatic adenocarcinoma are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
10 sites in 2 countries. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Allegheny General Hospital
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
-
Beth Israel Deaconess Medical Center - Division of Hematology/Oncology
RECRUITINGBoston, Massachusetts, 02215, United States
-
Brown University Cancer Institute
RECRUITINGProvidence, Rhode Island, 02906, United States
-
CAMBRIDGE CANCER TRIALS CENTRE-Addenbrooke's Hospital
RECRUITINGCambridge, Cambridge, CB2 0QQ, United Kingdom
-
Gary Weston Centre- Imperial College Healthcare- Du Cane Road
RECRUITINGHammersmith, London, W12 0HS, United Kingdom
-
Henry Ford Centre
RECRUITINGDetroit, Michigan, 48202, United States
-
HonorHealth Research Institute
RECRUITINGScottsdale, Arizona, 85258, United States
-
Sidney Kimmel Cancer Center, Thomas Jefferson University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
-
Stanford Cancer Center Palo Alto
RECRUITINGStanford, California, 94305, United States
-
The Royal Marsden- Downs Road
RECRUITINGSutton, Surrey, SM2 5PT, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Four-Drug cocktail aims to shrink pancreatic tumors before surgery
- Immune cells armed with antibody take on pancreatic cancer
- New drug AB801 aims to boost chemo and immunotherapy in tough cancers
- New PET tracer could light up pancreatic tumors
- New drug combo aims to tackle pancreatic cancer in patients with inherited gene mutations
- Blasting pancreatic tumors with extra radiation may open door to surgery