LIPOSARCOMA

This study is testing whether combining two drugs, mirdametinib and palbociclib, can help control advanced liposarcoma, a type of cancer that starts in fat tissue. Researchers will first find the safest dose of the combination, then see if it can keep the cancer from growing for …

This large international study is comparing two approaches for treating high-risk abdominal sarcomas (aggressive cancers in the belly). One group gets surgery alone, while the other gets chemotherapy first to shrink the tumor, followed by surgery. The goal is to see if adding che…

This early-stage study is testing whether a new drug called BTX-A51 is safe for people with advanced liposarcoma, a rare type of cancer. Researchers will give the drug to about 24 patients whose cancer has returned or spread, and monitor them closely for side effects. The study w…

This early-stage study is testing whether genetically modified immune cells can fight solid tumors in children and young adults. Researchers collect patients' own immune cells, modify them to better recognize and attack cancer cells, then infuse them back into the body. The study…

This early-stage study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific marker called GPC3. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, and then inf…

This study is testing a combination of chemotherapy drugs (ifosfamide, doxorubicin), a targeted drug (pazopanib), and sometimes a newer drug (selinexor) and radiation therapy for young patients (up to age 30) with rare soft tissue cancers. The goal is to see if this approach can …

This study is testing a new, unapproved pill called silmitasertib, given alongside standard chemotherapy drugs. It aims to find a safe and effective dose for children and young adults under 30 whose solid tumors (like neuroblastoma or sarcoma) have come back or stopped responding…

This study is testing whether selecting certain patients to receive proton radiation instead of standard X-ray radiation before sarcoma surgery can reduce long-term side effects while maintaining the same treatment effectiveness. For each of the 110 adult participants in Norway, …

This study is testing whether a newer type of radiation therapy, called proton beam therapy, can be given at a higher dose to better control inoperable soft tissue sarcomas. The goal is to see if this approach stops tumor growth for at least two years without increasing side effe…

This study aims to understand how personalized chemotherapy given before surgery works for patients with high-risk soft tissue sarcoma. Researchers will collect and analyze tissue samples from 800 patients, comparing those who receive chemotherapy before surgery to those who have…