KIDNEY DISEASE

This study tests a method called physiologic insulin resensitization (PIR) in 120 adults with advanced chronic kidney disease and type 2 diabetes. The goal is to see if PIR can improve kidney function and blood sugar control better than standard care. Participants will be randoml…

This study tests a new treatment called AdiaVita, made from umbilical cord stem cells and glutathione, in 100 adults with chronic kidney disease (stages 2-4). Participants receive monthly IV infusions for 3 months and use a skin spray at home. The goal is to see if the treatment …

This study tests a drug called mezagitamab for people with IgA nephropathy, a kidney disease where the body's immune system damages the kidneys. The main goal is to see if the drug reduces protein in the urine, a sign of kidney damage. About 347 adults will receive either mezagit…

This study tests whether an AI-powered health coach can help 300 adults with heart disease, diabetes, or kidney disease better manage their conditions. Participants use a smartphone app and monitoring devices to track health markers and get personalized guidance. The goal is to r…

This study tests whether red propolis, a natural bee product, can lower inflammation and oxidative stress in people with chronic kidney disease. Researchers will measure changes in inflammatory markers in 40 patients who are not yet on dialysis. The goal is to see if this supplem…

This study tests whether empagliflozin, a drug used for diabetes, can protect the kidneys and heart in people who have had a heart transplant. About 200 veterans will receive either the drug or a placebo daily for 12 months. The goal is to see if it improves kidney function and r…

This study tests a program called Inspire HER for Black women aged 30-79 with heart, kidney, and metabolic health issues. The program offers health education, physical activity, and social support to help lower heart disease risk. Researchers will see if the program is practical …

This study follows 100 women who had preeclampsia, HELLP syndrome, or kidney disease during pregnancy. Researchers measure blood vessel stiffness and collect blood samples to build a biobank. The goal is to better understand long-term heart and kidney health risks, not to test a …

This study collects health information, lifestyle details, and biological samples from up to 100,000 adults to help researchers better understand conditions like lupus, celiac disease, and kidney disease. The goal is to find new biomarkers and improve future tests and treatments.…

This study looks at how the drug eloralintide is processed by the body in people with severe kidney disease or kidney failure compared to healthy people. About 28 adults will receive a single injection under the skin. The study lasts about 14 weeks and aims to understand drug lev…

This study looks at a kidney disease called IgA nephropathy, which can lead to kidney failure. Researchers want to find special markers in the blood that could help diagnose the disease without needing a kidney biopsy. They will study 150 adults who need a kidney biopsy as part o…

This study tests if a digital education program helps people with type 2 diabetes and chronic kidney disease follow dietary guidelines for low sodium and optimal protein intake. About 104 adults aged 18-74 will participate. The main goal is to see if the program improves adherenc…

This study collects blood samples from 400 kidney transplant patients to help develop a non-invasive test that detects DNA from the donor kidney. The goal is to monitor the health of the transplanted organ without needing a biopsy. Participants must be 18 or older, have had a kid…

This study reviews medical records of about 10 adults who had a transplant and developed a difficult-to-treat CMV infection along with severe kidney disease or kidney failure. Researchers want to see how safe the drug maribavir is for these patients. The study does not change the…

This study aims to understand how genes influence kidney disease risk. Anyone 18 or older living in the US can join, even if they don't have kidney disease. Participants fill out online health surveys and provide a saliva sample by mail. In return, they may receive free informati…

This study tests a special scale that measures heart signals to predict when people on peritoneal dialysis might have too much fluid in their body. The goal is to see if the scale can give early warnings, reducing emergency visits and hospital stays. About 125 adults will use the…

This study aims to learn more about kidney diseases caused by the immune system, such as nephrotic syndrome and lupus nephritis. Researchers will follow up to 2,000 adults and children over 10 years old, collecting medical history, physical exams, and blood or urine samples. The …

This study looks at blood flow patterns in the kidneys and liver of adults admitted to the ICU after serious injuries. Researchers will use bedside ultrasound to check for abnormal patterns and see if they are linked to kidney failure or the need for a breathing machine. About 35…

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…