HUNTINGTON DISEASE

This study tests a new gene therapy called SPK-10001 for people with Huntington's disease. It involves a one-time infusion into specific areas of the brain. The main goals are to check safety and see if it can help control symptoms. About 53 adults with early-stage Huntington's w…

This phase 3 study tests whether the drug votoplam can slow the progression of Huntington's disease in people with early symptoms. About 770 adults aged 21 to 70 with confirmed Huntington's will receive either votoplam or a placebo. The main goal is to see if votoplam helps maint…

This study tests an oral medication called SKY-0515 in 400 adults aged 25 and older with Huntington's disease. The goal is to see if the drug can lower harmful proteins linked to the disease and improve movement, thinking, and daily function. Participants will be randomly assigne…

This early-stage trial tests whether implanting human neural stem cells into the brain is safe for people with Huntington's disease. About 21 adults aged 18-65 with a confirmed genetic diagnosis will receive the cells and be monitored for side effects. The goal is to see if the p…

This study is testing a blood test that can check for genetic disorders in unborn babies without the risks of traditional invasive tests. The test looks at fetal DNA found in the mother's blood as early as 9 weeks into pregnancy. Researchers aim to make this safe, accurate diagno…

This study tests whether a gentle brain stimulation technique called tDCS, done at home for 30 minutes each day, can improve thinking and behavior problems in people with Huntington's disease. Sixteen adults with early to moderate Huntington's will try the device and report their…

This study tests a gentle ultrasound treatment on the brain to see if it can safely improve movement issues like jerking and stiffness in people with Huntington's disease. About 24 adults with confirmed Huntington's will receive the treatment, and researchers will check for side …

This pilot study is testing whether adding music therapy to standard care can reduce irritability and impulsivity in 15 people with early-stage Huntington's disease. Participants will use a digital music tool over 3 months, and researchers will track changes in mood and behavior.…

This study tests a smartphone app designed to help people with Huntington's or Parkinson's disease feel less anxious. The app works by training users to interpret everyday situations in a less threatening way. Researchers will enroll 136 participants to see if the app improves an…

This study tests whether a gentle brain stimulation device (tDCS) used at home is safe and helpful for people with early to moderate Huntington's disease. Ten participants will use the device daily for several weeks. The goal is to see if it can improve mood, thinking, and other …

This study looks at two thinking and memory tests—the Coding Test and the SAGE—to see if they can help screen and track Huntington's disease. Researchers will compare these tests with standard ones in 76 adults aged 30-65 who have a genetic diagnosis of Huntington's. The goal is …

This study looks at a protein called BDNF in the spinal fluid and blood of people with Huntington's disease compared to healthy controls. The goal is to find biological markers that can help track the disease and guide future treatments. About 135 adults with confirmed Huntington…

This study uses special eye scans to look for early signs of brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will examine the tiny blood vessels and layers in the eyes of 2,000 adults—both healthy and with brain conditions—to see if eye changes c…

This study aims to collect health information from 600 people with Huntington disease (or those at risk) over 24 months using online surveys and remote tools. The goal is to understand how the disease progresses and identify factors that affect its speed. Participants can join fr…

This study aims to see if a test called DMASC-MC can detect problems with social thinking (like understanding others' feelings) in people with early Huntington disease. Researchers will compare results from 40 participants with Huntington disease to a control group. The goal is t…

This study is for people who carry the Huntington disease gene expansion. Participants visit the clinic once, answer questions about their health and background, and give a blood sample. The blood is tested to find specific genetic markers (SNPs) linked to the disease-causing and…

This study is testing whether wearable devices like smartwatches can accurately measure movement problems in people with Huntington's disease. About 100 participants, including those with Huntington's and healthy volunteers, will wear devices and answer surveys over several virtu…

This study tests a new radioactive tracer that may light up harmful protein clumps in the brains of people with Huntington's disease during a PET scan. About 27 adults with early-stage Huntington's or healthy volunteers will get one or two scans to see if the tracer works and is …

This study aims to see if the Hinting Task, a test that measures how well someone understands indirect speech, can reliably detect social cognition problems in people with Huntington's disease. Researchers will compare the performance of 52 adults with Huntington's to healthy con…