One-Time brain infusion aims to tame Huntington's

NCT ID NCT06826612

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 19, 2026 · Updated 32 times

Summary

This study tests a new gene therapy called SPK-10001 for people with Huntington's disease. It involves a one-time infusion into specific areas of the brain. The main goal is to see if it is safe and if it can slow down the worsening of movement and daily function. About 53 adults will take part in this early-phase trial.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43221, United States
University of Cincinnati/Cincinnati Children's Hospital
RECRUITING

Cincinnati, Ohio, 45221, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
University of Pittsburg
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

Conditions

The condition(s) this trial relates to.

choreatic disease Huntington disease movement disorder Rare Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUNTINGTON DISEASE