HUNTINGTON DISEASE

This early-stage study tested an experimental drug called ER2001 in 8 adults with early Huntington's disease. The main goal was to check if the drug is safe and how the body processes it. Participants received increasing doses of the drug through an IV over 6 weeks. This study is…

This study tested a stem-cell treatment called Cellavita HD in 49 adults with Huntington's disease. Participants received one of two doses or a placebo, and researchers tracked changes in motor skills over time. The goal was to see if the therapy could slow down the worsening of …

This study tested whether metformin, a common diabetes medicine, could help slow down thinking and memory problems in people with Huntington's disease. Sixty adults with Huntington's took either metformin or a placebo pill every day for a year. The goal was to see if metformin co…

This early study tested a new drug, ER2001, in 10 adults with early Huntington's disease. The main goal was to check if the drug is safe and how the body processes it. Researchers also looked for early signs that the drug might help control the disease.

This study tested an experimental drug called PTC518 in 159 adults with Huntington's disease. The main goal was to check the drug's safety and how it affects a key protein linked to the disease. Researchers also looked at brain scans and movement scores to see if the drug might s…

This study tested a drug called SAGE-718 in 69 people with early Huntington's disease to see if it could improve thinking and daily functioning. Participants took the drug or a placebo for 28 days. The main goal was to measure changes in cognitive abilities like memory and proble…

This study looked at whether taking weekly dance classes for 8 months can help people with Huntington's disease improve their movement, sense of control, and quality of life. Researchers also studied how dance affects the patients' partners and caregivers. The goal was to see if …

This study tested whether cognitive rehabilitation using immersive virtual reality or computer-based brain games could improve mild thinking problems in people with Parkinson's or Huntington's disease better than music therapy. 64 participants completed the trial, which compared …

This study looked at whether group drum classes could help people with Parkinson's or Huntington's disease feel better and move easier. Eighteen adults aged 18-89 took drum lessons twice a week for 12 weeks. Researchers checked their hand movement, mood, and overall well-being be…

This study looked at whether drinking caffeine is linked to how Huntington's disease progresses in people who have the gene but do not yet show symptoms. Researchers followed 77 adults for several years, measuring brain changes and thinking skills. The goal was to learn if caffei…

This study looked at how brain energy levels change as Huntington disease progresses. Researchers used a special type of MRI to measure energy-related chemicals in the brains of 50 adults with Huntington disease. No treatment was given; the goal was simply to understand the disea…

This early-stage study tested the safety and tolerability of an experimental drug called SAGE-718 in 6 people: healthy adults and patients with Huntington's disease. The main goal was to check for side effects and how the drug moves through the body. It was a Phase 1 trial, meani…

This completed study surveyed 131 people affected by Huntington's disease (HD) to learn about their feelings, attitudes, and beliefs toward clinical research. Participants included people with HD or those at risk, aged 18 and older, living in the United States. The goal was to he…

This study tested whether a treatment could improve brain energy use in people with early Huntington disease. Ten participants had special MRI scans to measure brain metabolism. The goal was to see if the treatment could help brain cells work better and slow the disease.