HPV INFECTION

This study looks at whether two doses of the HPV vaccine work as well as three doses for women aged 27 to 45. About 618 women will be randomly assigned to receive either two or three shots. The goal is to see if the immune response from two doses is strong enough to protect again…

This study tests a new 15-valent HPV vaccine to see if it is safe and triggers a strong immune response. It involves 330 healthy Chinese volunteers aged 9 to 45. Participants receive three doses of the vaccine or a placebo, and researchers monitor side effects and antibody levels…

This study looks at whether giving girls aged 9-14 a different HPV vaccine for their second dose is safe and works well. About 400 girls who have never had an HPV vaccine will get one type first, then a different type later. Researchers will check their immune response and any si…

This study tests an experimental vaccine that targets 11 types of HPV, the virus that causes cervical cancer. About 13,500 Chinese women aged 18-45 will receive either the vaccine or a placebo over 6 months. The goal is to see if the vaccine prevents serious cervical cell changes…

This study compares two ways to offer cervical cancer screening to women living with HIV: standard clinic-based screening versus adding community outreach where women receive HPV self-collection kits at home or other community spots. About 7,600 women will take part across multip…

This study tests an experimental vaginal suppository called Dysplasix in 45 women with high-risk HPV and mild cervical abnormalities (ASC-US or LSIL). Participants will use the suppository for 15 doses over 19 days and be monitored for two months. The goal is to see if the treatm…

This study tests whether same-day HPV testing and treatment can help prevent cervical cancer in 600 women living with HIV in the Dominican Republic. Cervical cancer is a leading cause of death in these women, but it is preventable with early detection. The goal is to see if this …

This study tests whether a non-invasive physical plasma treatment can clear HPV infections from the cervix. About 50 adults with HPV will receive the treatment, and researchers will check if the virus is gone afterward. If successful, this approach could help prevent cervical can…

This study tests whether a vaginal insert containing artesunate, a drug originally used for malaria, can help reverse high-grade cervical pre-cancer (CIN2/3) caused by HPV. About 78 women will receive either the drug or a placebo over three 5-day cycles. The main goal is to see i…

This study is testing a small, AI-powered camera called the Pocket colposcope to see if it can accurately detect early signs of cervical cancer in women who have tested positive for HPV. About 1,054 women in Kenya will use the device during a routine exam. The goal is to find a s…

This study explores whether women can accurately collect their own samples to test for HPV, the virus that can cause cervical cancer. Researchers will compare results from two different self-collection kits to standard Pap smears. The goal is to make screening easier and more acc…

This study looks at whether giving women a simple at-home kit to test for HPV (the virus that can cause cervical cancer) makes it easier for those who are overdue for screening to get tested. About 100 women aged 25-65 who haven't had a Pap smear in 3 years will receive a self-co…

This study is testing whether a special menstrual pad (Q-Pad) can accurately detect high-risk HPV from period blood collected at home. About 450 people who need a colposcopy after an abnormal Pap or HPV test will use the pad during their period and mail it to a lab. Researchers w…

This pilot study tests whether a daily supplement containing green tea extract (EGCG), folic acid, and vitamin B12 can help the body clear a high-risk HPV infection. About 100 women with a positive HPV test will take the supplement for several months. The main goal is to see if m…

This study follows 250 women living with HIV in Zimbabwe who have been treated for cervical pre-cancer. Researchers want to find out how often the disease returns and which tests best predict that return. Participants will have regular check-ups and tests every six months for two…

This study follows up with 100 people who took part in the ANRS IPERGAY trial to see how HPV infections relate to anal cancer risk over 10 years. Researchers will use special tests to find HPV molecular signatures and check for high-grade lesions or cancer. The goal is to better …

This study looks at whether people living with HIV can collect their own anal swab samples to test for HPV, a virus that can cause anal cancer, as accurately as a doctor can. About 400 adults with HIV in Reunion Island will try both methods and share which they prefer. The goal i…

This study looks at how often men with inflammatory bowel disease (IBD) have human papillomavirus (HPV) in their mouth and anus. Researchers will collect samples and survey participants to find out what factors increase the risk of infection. The goal is to better understand HPV …