HODGKIN LYMPHOMA

This study tests a new treatment for people with certain blood cancers (like leukemia, lymphoma, or multiple myeloma) that have come back or not responded to standard therapy. Participants receive chemotherapy followed by specially engineered natural killer (NK) cells from a dono…

This program provides access to an experimental drug called AVM0703 for people with various solid tumors or blood cancers who have not responded to other treatments. It is available in the US upon a doctor's request. So far, 37 patients have received the drug, and side effects ha…

This study tests a shorter course of a combination of drugs (BrECADD) in people with advanced Hodgkin lymphoma. The goal is to see if this approach can control the disease with fewer side effects. About 48 adults aged 18 to 60 will take part, and researchers will also check if a …

This early-stage study tests a new approach for people with certain lymphomas (like Hodgkin lymphoma) that have come back or not responded to standard treatments. Researchers take immune cells from healthy donors, add a special receptor (C7R) to help them survive longer, and targ…

This study gives people with blood cancers, immune disorders, and other serious diseases access to cord blood transplants that are not yet FDA-approved. It includes children and adults of any age. The main goal is to see how well the new blood cells grow after transplant.

This study is for people with blood cancers like leukemia or lymphoma who need a stem cell transplant from an unrelated donor. It compares two ways to prevent graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. One method uses a d…

This study tests a combination of four drugs (mosunetuzumab, polatuzumab, tafasitamab, and lenalidomide) in people with relapsed B-cell non-Hodgkin lymphoma. The goal is to see if this mix can shrink or control the cancer. About 36 adults who have already tried other treatments w…

This study tests whether adding the drug pembrolizumab to standard chemotherapy (GVD) can help people with Hodgkin lymphoma that has returned or not responded to initial treatment. About 257 participants will receive the combination, and those who respond well may go on to a stem…

This study tests a stem cell transplant using a person's own cells to treat Hodgkin and non-Hodgkin lymphoma. It includes people with HIV. The goal is to see if a radiation-free treatment plan helps patients live longer without their cancer returning. About 150 adults will take p…

This study tests whether a cord blood transplant (using stem cells from donated umbilical cord blood) can help children and young adults up to age 26 with blood cancers like leukemia or lymphoma. Participants receive the transplant as their first or second treatment. The main goa…

This study is for Indian adults with untreated stage 3 or 4 Hodgkin lymphoma. It tests how safe and effective a drug called brentuximab vedotin is when added to standard chemotherapy (AVD). Participants receive treatment for about 6 months and are monitored for side effects and c…

This study tests a two-step method using lower doses of radiation and chemotherapy before a stem cell transplant for people with various blood cancers or bone marrow failure. The goal is to see if this gentler approach reduces the chance of dying from the transplant itself. About…

This study tracks side effects of the drug ADCETRIS (brentuximab vedotin) when used with standard chemotherapy in children and teenagers with untreated Hodgkin lymphoma. Researchers will monitor for serious side effects like bone marrow suppression, nerve damage, and lung problem…

This study tests a combination of two drugs, nivolumab and ruxolitinib, in people with classical Hodgkin lymphoma that has returned or not responded to prior treatments. The goal is to find the safest dose of ruxolitinib when given with nivolumab and to see how well the combinati…

This study tests whether a combination of drugs called BV-AVD can effectively treat people with newly diagnosed, early stage bulky Hodgkin lymphoma. The treatment uses a targeted antibody to deliver chemotherapy directly to cancer cells, aiming to slow or stop cancer growth. Abou…

This study tests a new treatment for people with Hodgkin lymphoma whose cancer has come back or stopped responding to standard therapies. The treatment uses a patient's own immune cells, modified in a lab to better recognize and attack cancer cells. The goal is to find a safe dos…

This early-stage study tests a new drug called CTX-8371 in people with advanced cancers that have not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. About 85 adults with certain types of lung, breast, lymphoma, head and neck,…

This study tests whether two newer drugs (pembrolizumab and brentuximab vedotin) can shrink or eliminate Hodgkin lymphoma that has returned or not responded to initial treatment. About 84 adults who are eligible for a stem cell transplant will receive either the new drug combo or…

This study is for people with certain types of B-cell or Hodgkin lymphoma. Participants first get a stem cell transplant using their own cells, then receive a targeted drug called polatuzumab vedotin every 3 weeks for up to 8 doses. The goal is to see if this approach is safe and…

This study looks at how well the drug brentuximab vedotin works after a stem cell transplant in adults with Hodgkin lymphoma. About 70 participants will receive the drug as part of their regular care and be followed for up to 2 years. The goal is to see if the drug helps prevent …

This study compares two chemotherapy regimens (ABVD and A2VD) for people with newly diagnosed, early-stage Hodgkin lymphoma. Participants receive 3-4 cycles of chemotherapy, and a PET scan after 2 cycles helps doctors decide if further treatment or radiation is needed. The goal i…

This early-stage study tests a new type of stem cell transplant for children whose blood cancer or solid tumor has returned or is hard to treat. Doctors use a special method to remove certain immune cells from the donor's stem cells, then give a drug called zoledronate after tran…

This study looks at a new approach to collect stem cells for transplant in people with multiple myeloma, Hodgkin lymphoma, or non-Hodgkin lymphoma. The goal is to see if using a standard drug alone, with a second drug only when needed, can collect enough stem cells while possibly…

This study tests a stem cell transplant from a half-matched donor for people with blood cancers. Before the transplant, patients receive chemotherapy and low-dose radiation to prepare the body. The goal is to see if this approach helps the new stem cells grow and fight cancer wit…

This study tests a drug called tislelizumab in 28 adults with Hodgkin lymphoma who cannot receive standard chemotherapy due to age or health reasons. The goal is to see if the drug can shrink or control the cancer. Participants receive the drug intravenously every 3 weeks for up …

This study compares two first-line treatments for advanced Hodgkin lymphoma. One group gets the immunotherapy drug nivolumab combined with chemotherapy (AVD), while the other gets a standard chemo regimen (BEACOPP-like). The goal is to see which approach is safer and more effecti…

This study tests a new treatment for advanced Hodgkin lymphoma that combines the immunotherapy drug nivolumab with chemotherapy. Doctors use PET scans during treatment to see how well it's working and adjust therapy accordingly. The goal is to improve outcomes while reducing side…

This study tests whether a new form of the drug carmustine (without ethanol) causes fewer side effects than the standard version in lymphoma patients receiving a stem cell transplant. About 49 adults with Hodgkin or non-Hodgkin lymphoma who are already candidates for transplant w…

This study tests a new oral drug called AZD3470 in people with certain blood cancers, including Hodgkin and non-Hodgkin lymphoma. The goal is to see if the drug is safe and works, either alone or with other cancer treatments. About 161 adults and adolescents will take part in thi…

This study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in adults with blood cancers who are at high risk of rejecting a stem cell transplant. Participants receive the drug before standard transplant preparation to reduce DSA levels enough to al…

This study is for people with Hodgkin lymphoma that has come back or not responded to treatment. After a stem cell transplant, participants will receive a drug called a PD-1 inhibitor to help keep the cancer from returning. The goal is to see if this maintenance therapy improves …

This study tests whether giving a CMV vaccine to stem cell donors can protect transplant recipients from CMV infection. Donors receive the vaccine before donating stem cells, and the immunity is passed to the patient. The trial involves 216 people with blood cancers and aims to r…

This early-phase trial tests a vaccine (CMV-MVA Triplex) given to both stem cell donors and recipients to boost immunity against cytomegalovirus (CMV) and prevent active infection after transplant. About 46 people with various blood cancers or disorders will take part. The goal i…

This study looks at whether a 12-week high intensity interval training (HIIT) program is doable for young people who finished Hodgkin lymphoma treatment in the last two years. About 20 survivors aged 10-25 will try the program to see if it improves their heart health, body streng…

This study looks at whether a Mediterranean diet and exercise program can help lymphoma patients finish their chemotherapy and feel better during treatment. About 140 adults with Hodgkin or non-Hodgkin lymphoma who are starting chemotherapy will take part. The goal is to see if t…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study tests whether a tailored physical activity program can help preserve exercise capacity, heart function, memory, and quality of life in adults (ages 18-85) with Hodgkin or non-Hodgkin lymphoma or stage I-III breast cancer who are undergoing chemotherapy or other cardiot…

This study examines whether certain genetic differences make some women more likely to experience early menopause after chemotherapy for breast cancer or Hodgkin lymphoma. Researchers will analyze stored ovarian tissue from 50 women who had fertility preservation before treatment…

This study looks at how the body processes venetoclax when the tablets are crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured.…

This study looks at whether a tailored exercise program can slow down the aging process in people aged 50 and older who have survived blood cancers like leukemia or lymphoma. Researchers want to find out how much and what type of exercise is needed to make a difference. The goal …

This study looks at how social and genetic factors impact the long-term health of young adults who survived Hodgkin or non-Hodgkin lymphoma. Researchers will collect blood samples and health information from 2000 survivors to understand why some face more health problems after tr…

This study looks at how certain blood cell changes (called clonal hematopoiesis) after Hodgkin lymphoma treatment might be linked to later heart problems. Researchers will test blood samples from 190 survivors who received chemotherapy as children or young adults. The goal is to …

This research study aims to discover new genes that may increase the risk of childhood cancer. Researchers will collect blood samples and health information from 1,500 people in families where cancer clusters. The goal is to build a registry and sample bank to help future diagnos…

This study looks at how the bodies of children and young adults (ages 6-25) with Hodgkin or non-Hodgkin lymphoma break down certain drugs. Researchers will give small doses of probe medications during regular hospital visits and take blood samples to measure metabolism. The goal …

This study follows 250 young adults (ages 18-39) recently diagnosed with cancer to see how their social relationships and physical activity change over time and affect their quality of life. Researchers will track hospitalizations, treatment details, exercise habits, and well-bei…