HIV (HUMAN IMMUNODEFICIENCY VIRUS)

This study looks at whether people with HIV who have stopped taking their medication for at least 12 weeks can safely restart the same day they return to care. About 200 adults will take the once-daily pill B/F/TAF. Researchers will check if the virus stays under control and if p…

This study tests an enhanced combination treatment for depression in youth aged 15-24 who also have HIV. The approach uses regular symptom checks, a medication guide, and cognitive behavioral therapy tailored to this group. Researchers want to see if adding extra support strategi…

This early-stage trial tests a two-step approach to target hidden HIV. First, a drug called chidamide wakes up dormant HIV hiding in cells. Then, specially designed natural killer (NK) cells are infused to find and destroy those infected cells. The study enrolls 20 adults with we…

This study tests whether a combination of three existing drugs (topiramate, lenalidomide, and pyrimethamine) can wake up dormant HIV hiding in the body and help the immune system clear it. 30 adults with well-controlled HIV will receive the drugs in two phases to measure safety a…

This study tests a 3-session telehealth counseling program called IDEAS for Hope, delivered by nurses, to help people living with HIV in Tanzania who are having thoughts of suicide. The goal is to reduce suicide risk and improve engagement in HIV care. The study will enroll 600 a…

This study compares a one-visit point-of-care test and treat approach for hepatitis C against the usual multi-step process. About 1,280 people with or at risk for HIV, hepatitis B, or hepatitis C will take part. The goal is to see if the simpler method helps more people complete …

This study tests an experimental immunotherapy called PDS0101 in 27 adults aged 25-65 who have both HIV and HPV type 16. The goal is to see if the treatment is safe and can strengthen the immune system's fight against HPV, which can cause cancers of the cervix, anus, and other ar…

This study will check if a new rapid test device (MagIA H3S) can accurately detect HIV, hepatitis B, hepatitis C, and syphilis in 7,500 pregnant women in the Democratic Republic of the Congo. The goal is to see if this single test can replace multiple lab tests, making it easier …

This study will test a computer program that helps emergency room doctors spot patients who may have hepatitis C or HIV without knowing it. The tool uses patient data to suggest who should be tested. Researchers will compare this targeted approach to current screening methods to …

This study tests whether using two thermal ablation probes instead of one can better prevent cervical cancer in women living with HIV. Researchers will enroll 300 women in Rwanda to see if the new method is safe, acceptable, and improves treatment results. The goal is to reduce t…

This study tests whether a short course of the steroid prednisolone can prevent a serious condition called IRIS in people with AIDS who are starting HIV treatment. IRIS happens when the recovering immune system overreacts to hidden infections. The trial will enroll 262 participan…

This study will test whether using two probes during thermal ablation (a heat treatment) works better than the standard one-probe method to prevent cervical cancer in women living with HIV. About 300 women in Kenya will receive the new two-probe technique, and researchers will ch…

This study tests whether nurses can safely and effectively deliver long-acting injectable HIV prevention (cabotegravir) in public health clinics, especially in rural areas where access is limited. About 250 adults at risk for HIV will take part across multiple health departments …

This study looks at whether inflammation caused by HIV affects memory, attention, and thinking speed in teenagers. Researchers in Eswatini will compare 50 HIV-positive teens on antiretroviral therapy with 30 HIV-negative teens. They will measure inflammation markers in blood and …

This study will ask 1,800 young people and low-income adults in Lucerne and Zurich about their experience with free HIV and STI testing and counseling. Participants fill out a short survey after their visit to rate how satisfied they are. The goal is to see if these free services…

This early-stage study explores whether two different smell-based activities can improve smell and thinking in middle-aged and older adults with HIV. Eighty participants will either smell four scents twice daily or use a scent diffuser at night for 8 weeks. The main goal is to se…

This study looks at how two different vaginal products—estradiol cream and a moisturizer—affect menopause symptoms and vaginal health in women with HIV. About 62 women with HIV and menopause symptoms will use one of the treatments for 16 weeks. A separate group of women without H…

This study looks at how substance use may cause scarring and inflammation in the hearts of people with HIV. Researchers will use a special heart MRI to take detailed pictures of the heart. The study involves one visit and will include 400 adults from existing HIV study groups.

This study tests a computer tool that helps doctors pick the best combination of HIV medicines for each patient. The tool considers things like drug resistance, other health problems, and medication schedules. About 250 people with HIV and their doctors will take part. The goal i…

This study surveys 480 Italian dental students to understand their attitudes, knowledge, and any discriminatory behavior toward HIV-positive patients. Researchers want to see if students feel uncomfortable treating these patients and if they follow proper sterilization protocols.…