HEMATOLOGIC MALIGNANCIES

This study is for people living with HIV who also have a blood cancer that can be treated with a bone marrow transplant. Researchers want to see if a new mix of three drugs (cyclophosphamide, bortezomib, and maraviroc) can safely prevent graft-versus-host disease, a serious compl…

This study offers extra stem cells from a half-matched family donor to patients getting a cord blood transplant for serious blood cancers, immune problems, or inherited metabolic disorders. The goal is to help the bone marrow recover faster while the cord blood cells take over pe…

This early-stage trial tests a new drug called INCA036873 in about 280 adults with advanced solid tumors or certain blood cancers that have not responded to prior treatments. The main goals are to check the drug's safety and find the right dose. This study is not expected to cure…

This phase 2 trial tests whether giving immunoglobulin (antibody) replacement therapy can prevent serious bacterial infections in people receiving CAR-T cell therapy for blood cancers. CAR-T therapy often depletes the body's own antibodies, raising infection risk. The study will …

This study compares two approaches to prevent chronic graft-versus-host disease (GVHD) in 40 adults with blood cancers who receive a stem cell transplant. One group gets a lower dose of a standard drug (cyclophosphamide) followed by the drug ruxolitinib, while the other group get…

This study tests giving a special immune cell treatment (CAR T-cells) together with a half-matched bone marrow transplant for people with aggressive blood cancers like leukemia and lymphoma. The goal is to see if this combination is safe and can help prevent the cancer from comin…

This early-stage study tests a new drug called RJK-RT2831 in 71 adults with blood cancers. The main goals are to check safety, find the best dose, and see if the drug works. It is a first-in-human trial, so the focus is on understanding side effects and how the body processes the…

This study looks at the long-term safety and effectiveness of the cancer drug pembrolizumab (Keytruda) in people who have already been taking it in earlier studies. About 3,500 adults with solid tumors or blood cancers can join. The goal is to see how well the drug works over tim…

This study gives people with blood cancers, immune disorders, and other serious diseases access to cord blood transplants that are not yet FDA-approved. It includes children and adults of any age. The main goal is to see how well the new blood cells grow after transplant.

This study tests a personalized approach to stem cell transplants for adults with blood cancers like leukemia and lymphoma. The chemotherapy and radiation doses are adjusted based on each patient's risk factors to try to improve outcomes. The goal is to see if this tailored plan …

This study offers ongoing tafasitamab treatment to people with blood cancers who are already benefiting from it in a previous study. It aims to keep their disease under control while monitoring for side effects. About 25 adults who are tolerating the drug well and have stable or …

This study tests whether a cord blood transplant, given after a special conditioning therapy, can help control high-risk blood cancers in people whose first stem cell transplant stopped working. About 35 participants aged up to 60 will receive the treatment. The main goal is to c…

This study tests an experimental oral drug, MK-1026 (nemtabrutinib), in people with certain blood cancers like chronic lymphocytic leukemia, lymphoma, and Waldenstrom's macroglobulinemia. The goal is to see if the drug can shrink tumors and control the disease. About 490 adults w…

This study is for adults aged 65 and older with blood cancers who are getting a stem cell transplant. Researchers want to find the best dose of a drug called cyclophosphamide, which is given after the transplant to prevent the immune system from attacking the body. The goal is to…

This study tests whether a digital health app with remote monitoring can help 190 patients and their caregivers better manage symptoms and distress during and after CAR-T therapy for blood cancers. Patients use the app to report symptoms, and caregivers track their own stress lev…

This study tests a combination of two drugs (ICP-248 and orelabrutinib) in people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The goal is to see if the combo is safe and tolerable. About 226 adults aged 18 to 80 will take part. The approach aims to …

This early-stage study tests a new drug called IM-1021 in people with advanced solid tumors or certain blood cancers (lymphomas) that have not responded to other treatments. The main goals are to check the drug's safety and find the best dose. About 117 adults will take part in t…

This study is for people with blood cancers who are getting a stem cell transplant from a donor. It tests whether a lower dose of a drug called cyclophosphamide can prevent a serious side effect called graft-versus-host disease (GVHD), where donor cells attack the body. The goal …

This study tests an experimental inhaled drug called PUL-042 in 100 people with blood cancers (like leukemia or lymphoma) or those who have had a stem cell transplant. Participants have a viral lung infection (PIV, hMPV, or RSV). The goal is to see if PUL-042 can prevent the infe…

This study tests a new drug called SLS009 (formerly GFH009) in people with blood cancers like leukemia and lymphoma that have come back or not responded to treatment. It also tests SLS009 combined with two other drugs (venetoclax and azacitidine) in certain patients. The goal is …

This study tests a decision-support tool called PRIME for adults aged 60 and older with blood cancers like lymphoma, leukemia, or multiple myeloma. The tool helps patients clarify what matters most to them and shares that with their doctors. The goal is to see if using PRIME lead…

This study watches how BTK inhibitors, a type of leukemia treatment, affect the heart's rhythm. About 135 adults with certain blood cancers who are taking or about to start these drugs will have heart tests like EKGs, stress tests, and heart imaging. The goal is to spot dangerous…

This study looks at how the drug pralatrexate is processed by the body in people with advanced solid tumors or blood cancers who also have mild, moderate, or severe liver problems. Researchers will measure drug levels in the blood and track side effects. The goal is to find the r…

This study is collecting medical information and biological samples from 15,000 people receiving radiation therapy for cancer at Mayo Clinic. Researchers will analyze how treatment affects side effects, quality of life, and survival. The goal is to improve future care by linking …

This study aims to understand how a protein called CD56 appears in different blood cancers. Researchers will test blood or bone marrow samples from 38 newly diagnosed patients to see if CD56 is present and whether it relates to how the disease progresses. The goal is to gather kn…

This study is creating a large registry of lymphoma patients in Malawi to collect detailed information about the disease and its treatment. Researchers will enroll 800 people with suspected lymphoma, perform biopsies, and follow their health over time. The goal is to better under…