HELICOBACTER PYLORI INFECTION

This study tests whether adding a probiotic (Saccharomyces boulardii) to a standard 4-drug antibiotic regimen helps clear H. pylori infection in people whose past treatment failed. About 1,248 adults will be randomly assigned to get either the probiotic plus antibiotics or antibi…

This study compares two 10-day treatment plans for Helicobacter pylori, a stomach infection that can cause ulcers. Researchers want to see if a newer drug (tegoprazan) works better than the standard treatment in South Korea, where antibiotic resistance is common. About 400 adults…

This study looks at whether adding bismuth to the usual treatment helps clear H. pylori infection and heal stomach or duodenal ulcers in children. About 80 children will receive either a regimen with or without bismuth for 14 days, then take additional medication for 2-4 weeks. R…

This study looks at 2,600 adults with acute coronary syndrome who have had a stent placed and also have an H. pylori infection. They are given either a new drug (vonoprazan) plus amoxicillin or a standard acid reducer (pantoprazole) to see which better prevents stomach bleeding o…

This study tests two different 14-day treatments for H. pylori, a stomach infection that can cause ulcers. About 240 adults will take either tegoprazan or vonoprazan, both with the antibiotic amoxicillin. The goal is to see which combination kills the bacteria better and has fewe…

This study looks at different combinations of stomach acid-reducing drugs (P-CABs) with bismuth and antibiotics to treat H. pylori infection, a common cause of stomach ulcers. About 1,730 adults aged 18-70 with confirmed H. pylori will receive one of several treatment regimens. T…

This study tests a new way to treat H. pylori, a stomach infection that can cause ulcers. Doctors use a special gas (argon plasma) to treat fluid in the stomach, aiming to kill the bacteria during an endoscopy. The study involves 20 adults with untreated H. pylori. After the proc…

This study tests whether a newer acid-blocking drug (P-CAB) works better than a standard one (PPI) when used as part of a 4-drug therapy for H. pylori infection. About 320 adults who have not been treated before will take one of the two combinations. The goal is to see which trea…

This study tests a 'screen and treat' approach for H. pylori infection in 500 teenagers from three regions of Chile. Half will receive antibiotics to clear the infection, while the other half will not. Researchers will check if treatment reduces signs of stomach damage and change…

This study compares two 14-day treatments for H. pylori, a stomach infection that can cause ulcers. About 552 people will get either a new triple therapy (bismuth, amoxicillin, vonoprazan) or a standard quadruple therapy. The goal is to see which is more effective and safer, and …

This study tests a simpler treatment for H. pylori infection, a stomach bug that can cause ulcers. Researchers use a stool test to check if the bacteria are resistant to the antibiotic clarithromycin. If not resistant, patients take a two-drug combination (vonoprazan and clarithr…

This study tests whether choosing antibiotics based on lab tests (personalized) works better than standard antibiotic combinations for people whose H. pylori infection did not clear with first treatment. About 450 adults who failed prior therapy will be randomly assigned to one o…

This study tests whether a newer drug (vonoprazan) works better than a standard drug (esomeprazole) when combined with two antibiotics to treat H. pylori infection. About 80 adults with stomach discomfort and confirmed H. pylori will take one of the two treatments for 14 days. Fo…

This study looks at whether taking proton pump inhibitors (PPIs), common acid-reducing drugs, changes the accuracy of a stool DNA test for H. pylori infection. Researchers will test 25 adults who need long-term PPI therapy, comparing stool DNA test results while on PPIs and after…

This study follows 600 people at higher risk for stomach cancer to learn how precancerous changes in the stomach lining progress or reverse over time. Participants are adults aged 35-84 having an endoscopy for reasons like stomach pain or a family history of stomach cancer. Resea…