HEALTHY ADULTS

This Phase 1 trial tested a new HIV vaccine in 68 healthy adults to see if it is safe and triggers an immune response. The vaccine uses a DNA-based approach combined with an HIV protein to train the body to fight the virus. While early results are encouraging, this is just the fi…

This study tested a new home-use light device designed to kill bacteria on teeth. Twenty healthy adults compared the device plus regular brushing and flossing to brushing and flossing alone. The goal was to see if the light treatment could reduce leftover plaque more effectively …

This study looked at how an inhaled drug called treprostinil helps patients with pulmonary hypertension caused by interstitial lung disease. Researchers measured heart function and breathing efficiency during exercise after 3 months of treatment. The goal was to understand how th…

This study looked at whether a chicken extract supplement can improve mental energy—like focus, motivation, and tiredness—in healthy adults aged 35 to 64. About 189 people took either the extract or a placebo, and researchers measured their reaction time, attention, mood, and eve…

This study tested whether omega-3 supplements (a healthy fat found in fish oil) can reduce stress, anxiety, and depression while improving memory and sleep. 64 highly stressed Saudi adults took either omega-3 or a placebo daily for three months. Results showed that those taking o…

This completed Phase 1 study in 12 healthy adults tested how the antifungal drug fluconazole changes the way the body processes an experimental drug called PF-07248144. Participants took PF-07248144 alone and then again with fluconazole, and researchers measured drug levels in th…

This completed Phase 1 study by Pfizer enrolled 24 healthy adults to compare how two different tablet forms of the drug PF-07248144 are absorbed by the body. Participants received single doses of each form in a crossover design, with some taking the drug after eating. The goal wa…

This completed Phase 1 study looked at how two common drugs—cyclosporine (an immunosuppressant) and clarithromycin (an antibiotic)—affect the levels of a new medicine called PF-07328948 in the body. Twenty-six healthy adults received PF-07328948 alone and then with cyclosporine o…

This early-stage study tested a new oral drug called PF-07940369 in 30 healthy adults to see if it is safe and how the body processes it. Participants took the drug or a placebo once or twice daily for 14 days while staying at a clinic. The main goal was to check for side effects…

This study looked at how two common drugs (itraconazole and probenecid) change the way the body handles a new experimental medicine called PF-07220060. It involved 25 healthy adults who took the new medicine alone and then again with the other drugs. The goal was to understand po…

This completed Phase 1 study in 9 healthy adult men aims to understand how the experimental drug PF-07104091 is absorbed, broken down, and removed from the body. Participants received a radioactive-labeled version of the drug by mouth and later by IV, with samples collected over …

This study tested four different versions of the dietary supplement Urolithin A (Mitopure) in 48 healthy adults to see how well each is absorbed by the body. Participants took a single dose after fasting, and blood samples were collected over time. The goal was to understand whic…

This study tested whether a video game called Body-Brain Trainer, which combines physical movement with cognitive challenges, can improve attention and working memory in healthy adults. Forty-nine participants were assigned to different training groups for 8 weeks. The goal was t…

This study looked at how different levels of liver damage affect the way the body handles a single dose of the drug KP-001. Twenty-four adults, some with healthy livers and some with mild to moderate liver problems, took part. The goal was to measure drug levels in the blood and …

This early-stage study tested whether a new substance called CHI-554 is safe when taken with alcohol. 29 healthy adults took part. Researchers measured side effects, liver function, and blood alcohol levels. The goal was to gather safety information, not to treat any disease.

This completed study looked at how the drug carbamazepine changes the way the body handles a new medicine called PF-07220060. Fourteen healthy adults took PF-07220060 alone and then again after taking carbamazepine for several days. Blood samples were collected to measure drug le…

This study looked at how one session of aerobic exercise at different intensities affects brain blood flow, stress hormones, and memory in healthy adults and those with mild stress. Twenty-four people aged 20-40 took part. The goal was to understand the immediate benefits of exer…

This study looked for substances in blood and urine that can show what a person has eaten, instead of relying on memory or food diaries. Thirty-two healthy adults ate specially prepared meals for a week, and researchers tested their blood, urine, and stool samples. The goal was t…

This study looked at how the drug carbamazepine changes the way the body handles another drug called PF-07248144. Twelve healthy adults took PF-07248144 alone and then with carbamazepine. Researchers measured drug levels in the blood to understand the interaction and check for sa…

This study followed more than 5,000 adults aged 55–70 over nearly ten years to learn how retirement affects loneliness, physical activity, and overall well-being. Researchers interviewed participants three times between 2013 and 2019. The goal was to gather information, not to te…

This study looked for chemicals in blood and urine that can show what foods people have eaten, like beef, beans, and eggs. Thirty healthy adults ate controlled meals and gave samples over several days. The goal is to develop more accurate ways to measure diet than asking people t…

This study looked at whether taking a daily prebiotic supplement called SuperHMO (made from human milk sugars) for 30 days can improve gut health in healthy adults aged 18 to 40. 32 participants either took the supplement or a placebo. Researchers measured changes in gut bacteria…

This study looked at how bismuth subsalicylate (the active ingredient in Pepto-Bismol) changes the bacteria in the gut. 34 healthy adults took the medicine for 2 days, and researchers compared their stool samples before and after. The goal was to learn more about how this common …