HEADACHE
Clinical trials for HEADACHE explained in plain language.
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Eye ultrasound may spot spinal headache risk
Diagnosis CompletedThis study looked at whether measuring the optic nerve sheath with ultrasound can help predict a specific type of headache that can occur after spinal anesthesia. 176 adults having knee replacement surgery took part. The goal was to see if this simple eye test could identify who …
Matched conditions: HEADACHE
Sponsor: Ankara City Hospital Bilkent • Aim: Diagnosis
Last updated May 26, 2026 11:11 UTC
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Blood test may spot dangerous headaches in the ER
Diagnosis CompletedThis study looked at whether measuring a protein called S100B in the blood can help emergency doctors tell the difference between common headaches (like migraines) and headaches caused by a more serious problem (like bleeding or infection). 81 adults with bad headaches but no rec…
Matched conditions: HEADACHE
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Diagnosis
Last updated May 14, 2026 12:05 UTC
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IV fluids for migraine in kids: simple solution?
Symptom relief CompletedThis study looked at whether giving children with migraine just intravenous (IV) fluids in the emergency department can ease their headache pain. 46 children took part. Researchers measured pain, nausea, and whether more medicine was needed later. The goal was to see if hydration…
Matched conditions: HEADACHE
Phase: PHASE1, PHASE2 • Sponsor: University of Alberta • Aim: Symptom relief
Last updated May 26, 2026 11:19 UTC
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Hands-On therapy and Brain-Body exercises show promise for Jaw-Related headaches
Symptom relief CompletedThis study looked at whether manual therapy (hands-on treatment) plus a cognitive exercise therapy approach (BETY) could reduce headache pain and improve quality of life in people with temporomandibular disorder (TMD)-related headaches. Sixty adults aged 18 to 60 with TMD headach…
Matched conditions: HEADACHE
Phase: NA • Sponsor: Hasan Kalyoncu University • Aim: Symptom relief
Last updated May 26, 2026 11:17 UTC
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Nasal nerve block offers new hope for spinal headache sufferers
Symptom relief CompletedThis study tested a nerve block (SPGB) using numbing medicine sprayed into the nose to treat severe headaches that can happen after a spinal needle accidentally punctures the fluid sac around the spine. 26 adults who developed this headache were randomly assigned to get the nerve…
Matched conditions: HEADACHE
Phase: NA • Sponsor: ISSSTE Hospital Regional "Gral. Ignacio Zaragoza" • Aim: Symptom relief
Last updated May 26, 2026 11:13 UTC
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New nerve zap eases stubborn headaches
Symptom relief CompletedThis study tested a nerve treatment called pulsed radiofrequency for people with cervicogenic headache (headache coming from the neck). 25 adults who did not get relief from standard treatments received the procedure. The goal was to see if it could lower headache pain and reduce…
Matched conditions: HEADACHE
Phase: NA • Sponsor: Ankara City Hospital Bilkent • Aim: Symptom relief
Last updated May 26, 2026 11:12 UTC
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Can a blood pressure drug ease veterans' post-concussion headaches?
Symptom relief CompletedThis study tested whether prazosin, a drug often used for high blood pressure, can reduce the frequency and severity of chronic headaches in veterans and service members who had a mild traumatic brain injury. 89 participants took either prazosin or a placebo for 12 weeks. The goa…
Matched conditions: HEADACHE
Phase: PHASE1, PHASE2 • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated May 26, 2026 11:07 UTC
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Zapping a nerve to beat long COVID fatigue?
Symptom relief CompletedThis pilot study tested whether vagal nerve stimulation could reduce fatigue and headaches in people with Post-COVID syndrome. 18 participants used the device and reported changes in their symptoms. The goal was to see if this approach is worth studying further.
Matched conditions: HEADACHE
Phase: NA • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated May 11, 2026 20:48 UTC
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Can a brisk walk reshape your brain? new study investigates
Knowledge-focused CompletedThis study looked at how walking exercise and changes in body fat relate to brain structure in 22 overweight adults with headaches. Participants either followed a diet plus a 12-week walking program or diet alone. Brain scans and body fat measurements were taken before and after …
Matched conditions: HEADACHE
Phase: NA • Sponsor: Amasya University • Aim: Knowledge-focused
Last updated May 26, 2026 11:12 UTC
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AI-Written summaries make brain MRI reports easier to understand
Knowledge-focused CompletedThis study tested whether adding a simple AI-written summary to brain MRI reports helps people better understand the results. Over 2700 adults read fictional MRI reports for headaches and answered questions about what they found. The goal was to see if the AI summary improved und…
Matched conditions: HEADACHE
Phase: NA • Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated May 19, 2026 11:59 UTC
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Heart drug tested as migraine shield in small study
Knowledge-focused CompletedThis study tested whether ivabradine, a medicine that slows the heart rate, could prevent migraine attacks triggered by a substance called levcromakalim. Thirty-seven adults with migraine without aura took part. Researchers measured how many migraine attacks occurred after taking…
Matched conditions: HEADACHE
Phase: NA • Sponsor: Danish Headache Center • Aim: Knowledge-focused
Last updated May 19, 2026 11:47 UTC