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Jaw pain headaches? Hands-On therapy and Brain-Body exercises show promise

NCT ID NCT05927545

Symptom relief Sponsor: Hasan Kalyoncu University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at whether manual therapy (hands-on treatment) and a cognitive exercise therapy approach (BETY) can reduce headache pain and improve quality of life in people with temporomandibular disorder (TMD)-related headaches. 60 adults with TMD headaches were split into groups receiving either education and exercises alone, or combined with manual therapy or BETY. The goal was to see if these treatments help with pain, jaw function, sleep, and mood over 8 weeks and 5 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Manual therapy and cognitive exercise therapy (BETY) approach
What this could lead to
If successful, this could point toward effective non-drug treatments for headaches caused by jaw joint problems, improving pain and daily function.
What could go wrong
This is a small, completed trial with 60 people, so results may not apply to everyone. The treatments are physical therapies, not a cure, and benefits may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Sep 2023

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ages between 18 and 60 years old * Getting a diagnosis of TMD-related headache * Not having received FTR and manual therapy in the last 3 months * Having pain ≥ 50 or more according to the headache impact test (HIT 6) * Patients who have not received medical treatment in the last 3 months and will not receive medical treatment during the treatment * Patients who describe pain in the jaw, face, temporal region or ear for at least 6 months and who have pain in the chewing muscles with palpation Exclusion Criteria: * Ages under 18 and over 60 years old * Patients with disc displacement and/or attachment degeneration * Patients with dental infection * Patients who have undergone facial and ear surgery in the last six months * Patients undergoing orthodontic treatment * Patients using regular analgesics or anti-inflammatory drugs * Patients with a history of trauma (whiplash injury, condylar trauma, fracture), * Patients who have undergone any surgery related to the cervical and/or TMJ * Patients with facial paralysis * Patients with missing teeth in the upper jaw * Patients with cognitive deficits * Participation rate lower than 80% of the program schedule

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Conditions

The condition(s) this trial relates to.

Headache headache disorder Pain temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Headache Temporomandibular disorders

Contacts and locations

Locations

  • Abdulkadir Konukoğlu Sağlıklı Hayat Merkezi

    Gaziantep, 27560, Turkey (Türkiye)

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