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Walking may boost brain health in overweight adults, small study hints

NCT ID NCT07425093

Knowledge-focused Sponsor: Amasya University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a 12-week walking program could change brain structure in 22 overweight adults who also had headaches. Participants either followed a diet plus walking or diet alone. Researchers measured brain gray and white matter volumes with MRI scans before and after the program. The goal was to see if exercise-related fat loss might benefit the brain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Walking exercise program
What this could lead to
If successful, this could show that simple walking helps preserve or improve brain structure in people who are overweight.
What could go wrong
This is a very small, completed study with only 22 participants. Results may not apply to everyone, and it only looks at short-term changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

22 people

The number who actually took part.

Started

Jan 2024

Finished

Mar 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults aged 19-65 years 2. Body Mass Index (BMI) ≥25 kg/m² 3. Presented to the neurosurgery department with headache complaints between January 1, 2024 and March 1, 2024 4. Underwent brain magnetic resonance imaging (MRI) between January 1, 2024 and March 1, 2024 5. Completed baseline blood tests between January 1, 2024 and March 1, 2024, including: * Fasting blood glucose * Lipid profile (total cholesterol, LDL, HDL, triglycerides) * Liver enzymes (ALT, AST, GGT) * Thyroid function tests (T3, T4, TSH) * Vitamin B12 * Complete blood count (hemogram) * Hemoglobin A1c (HbA1c) 6. Scheduled for routine 6-month follow-up blood work based on initial test results 7. Willing to undergo follow-up brain MRI at 12 weeks (costs covered by research team) 8. Willing and able to attend 6 biweekly nutrition counseling sessions over 12 weeks with the study dietitian 9. Willing and able to attend 6 biweekly body composition measurement appointments over 12 weeks 10. No diagnosed chronic conditions including hypertension or diabetes 11. Owns a smartphone and is proficient in using smartphone applications for heart rate monitoring and step counting Exclusion Criteria: 1. Did not present to the neurosurgery department with headache complaints between January 1, 2024 and March 1, 2024 2. Did not undergo brain MRI between January 1, 2024 and March 1, 2024 3. Did not complete required baseline blood tests (fasting glucose, lipid profile, liver enzymes, thyroid function, vitamin B12, hemogram, HbA1c) between January 1, 2024 and March 1, 2024 4. BMI \<25 kg/m² 5. Unable or unwilling to attend 6 biweekly nutrition counseling sessions over 12 weeks 6. Unable or unwilling to attend 6 biweekly body composition measurement appointments over 12 weeks 7. Diagnosed chronic diseases including hypertension or diabetes 8. Unable to use smartphone applications for heart rate monitoring and step counting, or does not own a smartphone 9. Physical disabilities that would prevent walking exercise 10. Current use of antidepressant medications 11. Currently engaged in regular exercise programs 12. History of cerebrovascular disease (stroke, transient ischemic attack) 13. Diagnosis of epilepsy 14. Diagnosis of Multiple Sclerosis or Alzheimer's disease 15. Conditions affecting brain ventricular volume (e.g., hydrocephalus) 16. Pregnancy 17. Currently breastfeeding

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Conditions

The condition(s) this trial relates to.

Headache headache disorder Motor Activity Obesity obesity disorder Overweight Sedentary Behavior Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Body fat percentage Brain grey matter Brain white matter Headache Obesity / overweight Sedentary lifestyle

Contacts and locations

Locations

  • Amasya Sabuncuoglu Serefeddin Training and Research Hospital

    Amasya, 05100, Turkey (Türkiye)

  • Kolmed Hospital

    Amasya, 05100, Turkey (Türkiye)

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