GLIOBLASTOMA MULTIFORME

This early-phase study tested a new drug called 177Lu-FF58, which delivers radiation directly to cancer cells that have specific markers (integrins). The goal was to check safety, find the right dose, and see if it shrinks tumors in people with advanced pancreatic, stomach, or br…

This study tested a new drug called VAL-083 in people with glioblastoma, an aggressive brain cancer, that had come back after standard treatments. The goal was to see if VAL-083 could help patients live longer. However, the trial was stopped early after only 2 people enrolled, so…

This study tested a new radioactive imaging agent called [68Ga]-FF58 to see how well it could detect certain solid tumors, including glioblastoma, breast cancer that spread to the brain, gastroesophageal cancer, and pancreatic cancer. The study was early-phase and involved 14 adu…

This early-phase study tested whether the antifungal drug posaconazole can enter brain tumors in high enough amounts to stop cancer cells from dividing. Seven adults with glioblastoma took the drug before surgery so researchers could measure drug levels in their spinal fluid and …

This early-phase study aimed to see if ketoconazole, a drug used for fungal infections, could enter glioblastoma brain tumors in high enough amounts to stop cancer cells from dividing. Only one person was enrolled before the study was terminated. The goal was to gather informatio…

This study looked at whether a liquid biopsy—testing the fluid around the brain and spinal cord—can find tumor DNA in children and young adults with brain tumors. Researchers collected extra samples during routine care from up to 57 participants. The goal was to see if this safer…