GLIOBLASTOMA MULTIFORME

This early-stage study is testing the safety and feasibility of a new cell therapy for aggressive brain tumors in adults and children. Doctors will collect a patient's own immune cells, modify them in a lab to better target cancer cells, and then infuse them back into the patient…

This early-stage study is testing the safety and finding the right dose of an experimental oral drug called DSP-0390 for adults whose aggressive brain tumors (high-grade gliomas) have returned. The main goals are to see what side effects occur and to measure how the drug behaves …

This study is testing a new drug called ST101 for people with advanced solid tumors that have not responded to other treatments. The main goals are to find a safe dose and see if the drug can help control cancers like glioblastoma, melanoma, breast cancer, and prostate cancer. Th…

This early-stage study is testing a drug called niraparib for two types of aggressive brain cancer. It first checks if the drug reaches the tumor effectively after a short pre-surgery dose. If it does, participants can continue taking the drug, sometimes with radiation, to try to…

This study is testing an oral drug called ACP-196 (acalabrutinib) for adults whose aggressive brain cancer, glioblastoma, has returned after one or two prior treatments. The main goal is to see if the drug can shrink tumors and is safe for patients. It is an early-phase trial for…

This early-stage study is testing whether adding an experimental drug called S-Gboxin to standard brain cancer treatment is safe and effective. It involves 10 adults with aggressive brain tumors like glioblastoma who have already tried standard treatments. Researchers will monito…

This early-stage study is testing a new antibody drug called APX005M in children and young adults with brain tumors that have come back or stopped responding to standard treatments, or with a newly diagnosed, aggressive type of brain stem glioma. The main goal is to find the safe…

This study aimed to test a new treatment for children whose aggressive brain tumors had returned. The treatment involved injecting a specially engineered virus directly into the tumor, followed by a single low dose of radiation. The goal was to see if this combination could help …

This study is testing if aiming a higher dose of radiation at a specific area of the brain, called the subventricular zone, can help control a fast-growing brain tumor (glioblastoma) for longer than standard radiation. Patients receive the usual chemotherapy alongside the radiati…

This study is testing whether adding the antiviral drug valganciclovir to standard glioblastoma treatment helps patients live longer. It involves 220 adults with newly diagnosed glioblastoma who will receive either the antiviral or a placebo alongside their standard chemotherapy …

This study is testing whether adding an experimental drug called BPM31510 to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma, an aggressive brain cancer. The main goal is to see if this combination can delay cancer progression and extend surv…

This trial is testing whether adding an experimental drug called LAM561 to standard treatment helps people newly diagnosed with an aggressive brain cancer called glioblastoma. About 144 participants will receive either LAM561 or a placebo pill along with their standard radiation …

This study is testing whether an oral cancer drug called ribociclib can get into the brain and reach recurrent brain tumors. It involves 48 adults with recurrent high-grade glioma or meningioma who are scheduled for surgery. Patients take the drug for a short time before their op…

This early-stage trial is testing if adding high-dose vitamin C (given by IV) and an iron-based drug called ferumoxytol to the standard treatment for glioblastoma brain tumors is safe and helpful. The study involves about 17 adults who have just been diagnosed. The main goal is t…

This early-stage trial is testing whether combining two immunotherapy drugs with a precise, high-dose radiation treatment is safe and might help control recurrent glioblastoma, a very aggressive brain cancer. The study involves about 16 patients whose cancer has returned after in…

This early-stage study is testing the safety of a new, one-time gene therapy called Temferon for patients with a specific, hard-to-treat form of glioblastoma brain cancer. Doctors take a patient's own blood stem cells, genetically modify them to produce a cancer-fighting protein,…

This study is testing a cancer vaccine called SurVaxM in children and young adults with aggressive brain tumors that have come back or progressed. The vaccine is designed to teach the body's immune system to find and destroy cancer cells that carry a specific protein called survi…

This is a first-in-human safety study testing a genetically engineered virus, rQNestin34.5v.2, as a potential treatment for recurrent malignant brain tumors (gliomas). The virus is designed to infect and kill only cancer cells while sparing healthy brain tissue. The main goals ar…

This study is testing whether adding high-dose vitamin C given through an IV can improve outcomes for adults with a serious type of brain cancer called glioblastoma. All 90 participants will receive the vitamin C infusions along with the standard treatment of radiation and chemot…

This study is testing if a new drug called NanO2 can help standard radiation and chemotherapy work better for people newly diagnosed with glioblastoma, a fast-growing brain tumor. The idea is that NanO2 delivers extra oxygen to the tumor, which may make radiation therapy more eff…

This program provided gallium maltolate (GaM) capsules to adults with glioblastoma that had returned or stopped responding to standard treatments. Patients took one capsule daily by mouth at home for 28-day cycles. The goal was to offer a potential treatment option when no other …

This early-stage trial is testing a new drug called AZD1390 in combination with standard radiation therapy for adults with aggressive brain tumors (grade 4 glioma or glioblastoma). The study first checks if the drug successfully reaches the tumor tissue. Patients whose tumors sho…

This early-stage trial is testing whether giving immunotherapy drugs before surgery helps the body's immune system fight recurrent glioblastoma, a fast-growing brain cancer. About 63 participants will receive either one drug, a combination of two drugs, or a placebo before their …