GENETIC PREDISPOSITION

This study tests whether a genetic test can help decide which leukemia patients need a strong antifungal drug (posaconazole) to prevent serious mold infections during chemotherapy. About 410 adults with acute myeloid leukemia will be randomly assigned to receive the drug or a pla…

This study tests whether applying minoxidil (a hair growth drug) to the breasts for two weeks before surgery can improve blood flow and tissue survival in women undergoing preventive mastectomy with reconstruction. Twenty-five women at high genetic risk for breast cancer will hav…

This study looks at how a person's genetic makeup influences their response to oral semaglutide, a drug used for type 2 diabetes. Researchers will give 125 people with prediabetes the drug for 14 days and measure blood sugar, fat, and protein levels after a standardized breakfast…

This study is testing a new online platform called Nest for young adults aged 18-39 who have had genetic testing for cancer risk. The platform gives both patients and their doctors access to updated information about genetic findings. Researchers want to see if the tool is easy t…

This study looks at 1,000 people with alcohol-related liver disease to understand how their genes and drinking habits together raise the risk of liver cancer. Researchers will analyze DNA and lifestyle factors to create a risk score that could help doctors decide who needs regula…

This study is creating a registry of 100 women who have had a heart attack or unstable angina. Researchers will collect genetic, biochemical, and molecular data to understand how symptoms and disease patterns may vary among women. The goal is to identify subtypes of heart disease…

This study aims to learn more about genetic diseases that affect the heart and blood vessels. Researchers will collect medical data and samples (like blood, urine, and tissue) from people with these conditions, their relatives, and healthy volunteers. The goal is to improve diagn…

This study looks at how parents and children (ages 10-24) talk about the child's genetic risk for cancer. Researchers want to find what helps or hinders these conversations, so they can create better education and support for families. About 125 participants will be observed and …

This study aims to better understand and treat people with certain inherited metabolic or genetic disorders. Researchers will use standard medical tests like blood work and imaging to diagnose and care for participants, who may also join other related studies. The goal is to expa…

This study compares two ways of providing pre-test education for cancer genetic testing: a chatbot (called GIA) versus a live genetic counselor. About 96 adults at high risk for certain cancers will be randomly assigned to one of the two methods. The main goal is to see if the ch…

This study is building a collection of prostate tissue samples from people who carry certain gene mutations (like BRCA1/2) that raise their risk for aggressive prostate cancer. Researchers will compare these samples with those from people without the mutations to learn how the ca…

This study looks at whether a genetic test can help predict prostate cancer risk in men who have or are at high risk for the disease. Researchers will analyze DNA from 3000 men to find rare and common genetic changes linked to prostate cancer. The goal is to see if this informati…

This study follows 56 adolescents and young adults who have a genetic condition that raises their cancer risk. Researchers want to see if these patients find adult doctors and continue getting regular cancer screenings after they leave pediatric care at St. Jude Children's Resear…

This study looks at genetic changes in families to figure out which ones truly increase cancer risk. Researchers will analyze DNA from 11,000 people, including those with certain gene variants and their relatives. The goal is to improve genetic counseling and help doctors decide …

This study follows 20,000 people who have a family history of pancreatic cancer or carry certain gene changes that raise their risk. Researchers will track them over time to learn how to detect pancreatic cancer earlier and possibly prevent it. The goal is to improve survival by …

This study looks back at genetic test results from about 12,000 people with rare diseases or family cancer syndromes. Researchers want to see how often newer DNA sequencing methods find a diagnosis compared to older tests. No new treatments are given; the goal is to learn which t…

This study looks for new genetic reasons why some people get cancer at a young age. About 5-10% of cancers are linked to inherited gene changes, but standard tests don't always find them. Researchers will use a more detailed genetic test called exome sequencing on 613 patients wh…

This study looks at how certain genes increase the risk of liver cancer (hepatocellular carcinoma) in people with nonalcoholic fatty liver disease (NAFLD). Researchers will follow 500 adults aged 45-75 with NAFLD to understand how genetic factors and lifestyle interact. The goal …