GENETIC PREDISPOSITION

This study tests whether using a person's genetic risk for mold infections can guide the use of an antifungal drug (posaconazole) to prevent serious fungal infections in adults with acute myeloid leukemia (AML) undergoing chemotherapy. About 410 participants will be randomly assi…

This study tests whether applying minoxidil (a hair growth cream) to the breasts for two weeks before surgery can improve blood flow and tissue survival in women undergoing preventive mastectomy with reconstruction. About 25 women at high genetic risk for breast cancer will parti…

This study is testing a new online platform called Nest for young adults aged 18-39 who have had genetic testing for cancer risk. The platform gives patients and their doctors updated information about gene changes that may increase cancer risk. Researchers want to see if the too…

This study aims to learn more about diseases of the heart and blood vessels by collecting medical information and samples from 1,000 people, including those with genetic conditions, their relatives, and healthy volunteers. Participants aged 2 and older will undergo various tests …

This study compares two ways of providing pre-test education for cancer genetic testing: a chatbot (GIA) versus a human genetic counselor. About 96 adults at high risk for certain cancers will be randomly assigned to one of the two methods. The main goal is to see if using a chat…

This study looks at whether a genetic test can help predict prostate cancer risk in men who have or are at high risk for the disease. Researchers will analyze DNA from 3000 men to find rare and common genetic changes linked to prostate cancer. The goal is to see if this informati…

This study follows 56 adolescents and young adults who have a genetic condition that raises their cancer risk. Researchers want to see if these patients find adult doctors and continue getting regular cancer screenings after they leave pediatric care at St. Jude Children's Resear…

This study looks at genetic changes in families to figure out which ones truly increase cancer risk. Researchers will analyze DNA from 11,000 people, including those with certain gene variants and their relatives. The goal is to improve genetic counseling and help doctors decide …

This study is building a registry of 100 women who have had a heart attack (acute coronary syndrome). Researchers will analyze their genes and blood markers to find differences in how heart disease affects women. The goal is to identify subtypes that could lead to better, more pe…

This study looks at how a person's genetic makeup influences their response to oral semaglutide (Rybelsus), a drug used for type 2 diabetes. About 125 adults with normal blood sugar or prediabetes will take the drug for 14 days. Researchers will measure blood sugar, fat, and othe…

This study looks at how parents and children (ages 10-24) talk about the child's genetic risk for cancer. Researchers want to find out what helps or hinders these conversations, and how they affect the child's feelings and health choices. The goal is to improve genetic education …

This study follows 20,000 people who have a family history of pancreatic cancer or carry certain gene changes that raise their risk. Researchers will track them over time to learn how to detect pancreatic cancer earlier and possibly prevent it. The goal is to improve survival by …

This study looks back at genetic test results from about 12,000 people with rare diseases or family cancer syndromes. Researchers want to see how often newer DNA sequencing methods find a diagnosis compared to older tests. No new treatments are given; the goal is to learn which t…

This study looks at how a person's genes and their environment (like alcohol use) interact to cause liver cancer in people with alcohol-related liver disease. Researchers will study 1000 participants to find new genetic variants that increase cancer risk. The goal is to better un…

This study looks for new genetic reasons why some people get cancer at a young age. About 5-10% of cancers are linked to inherited gene changes, but standard tests don't always find them. Researchers will use a more detailed genetic test called exome sequencing on 613 patients wh…

This study looks at how certain genes increase the risk of liver cancer (hepatocellular carcinoma) in people with nonalcoholic fatty liver disease (NAFLD). Researchers will follow 500 adults aged 45-75 with NAFLD to understand how genetic factors and lifestyle interact. The goal …

This study is building a collection of prostate tissue samples from people with inherited gene mutations that raise their risk for aggressive prostate cancer. Researchers will compare these samples to those from people without such mutations to learn how the disease develops and …