GBM

This study tests a new treatment for glioblastoma, a serious brain cancer. It combines an investigational drug (5-ALA) with a non-invasive ultrasound device to target tumor cells. About 103 people with newly diagnosed glioblastoma will be randomly assigned to get either the activ…

This study tests a more precise way to place electrodes on the scalp for glioblastoma patients receiving Optune therapy, which uses electrical fields to kill cancer cells. Researchers use advanced MRI to map the full extent of the tumor and guide electrode placement. The goal is …

This study tests a new drug called LMP744 in 40 adults whose glioblastoma (a type of brain cancer) has come back after standard treatment. The drug is given through a vein for 5 days each month for up to a year. The goal is to see if it can shrink tumors or slow their growth.

This early study tests a new treatment for glioblastoma, an aggressive brain cancer that has come back after prior therapy. The approach combines an investigational drug (5-ALA) with focused ultrasound waves to target and damage tumor cells before surgery. Only 11 participants wi…

This early-phase study tests a new approach for people with recurrent high-grade astrocytoma, a serious brain cancer. Participants receive a virus-based gene therapy injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the safest…

This study tests whether adding an experimental drug called silevertinib to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer growing. The trial is for patients whose tumors have certain genetic…

This early-stage trial tests a special helmet that uses focused ultrasound to temporarily open the blood-brain barrier in people with glioblastoma, a severe brain cancer. The goal is to see if this approach is safe and can help standard chemotherapy reach the tumor more effective…

This trial tests a device called SonoCloud-9 that uses ultrasound to temporarily open the blood-brain barrier, allowing more chemotherapy (carboplatin) to reach brain tumors. About 560 adults with recurrent glioblastoma will either get this new combination or standard chemotherap…

This study tests if a drug called niraparib works better than the standard chemo (temozolomide) for adults with a newly diagnosed, aggressive brain cancer called glioblastoma that has a specific genetic marker (MGMT unmethylated). About 450 people will be randomly assigned to tak…