FRONTOTEMPORAL DEMENTIA

This study tests whether metformin, a common diabetes medicine, is safe and tolerable for people with a specific genetic form of ALS (C9orf72 ALS). About 41 participants will take metformin for 24 weeks. Researchers will monitor side effects and measure changes in harmful protein…

This study tests a single-dose gene therapy (LY3884963) in 35 adults with frontotemporal dementia caused by a progranulin gene mutation. The goal is to see if it safely raises progranulin levels in the body and brain, which may slow disease progression. Participants receive one o…

This study tests a single dose of a gene therapy called PBFT02 in 30 adults with frontotemporal dementia caused by specific gene mutations. The treatment aims to deliver a working copy of the GRN gene to the brain to help control the disease. Researchers are primarily checking sa…

This study tests an experimental drug called DNL593 for frontotemporal dementia, a brain disease that affects personality and language. First, healthy volunteers receive a single dose to check safety. Then, people with the disease receive multiple doses over 25 weeks to see if th…

This study explores whether making music together can improve social attention and feelings of closeness between people with mild to moderate frontotemporal dementia or Alzheimer's disease and their caregivers. About 80 patient-caregiver pairs will take part in rhythmic musical a…

This study collects blood samples every 3 months for 3 years from people who carry gene mutations linked to frontotemporal dementia (FTD), a brain disease that affects personality and language. The goal is to see if a protein called neurofilament light chain (NfL) changes over ti…

This study is collecting samples and data from 610 people with ALS and related disorders, as well as healthy volunteers. The goal is to track natural changes in biological markers over time, which will help researchers design better future clinical trials. Participants do not rec…

This study aims to learn more about ALS and similar diseases like frontotemporal dementia and hereditary spastic paraplegia. Researchers will look at participants' symptoms, genetic information, and biological markers to find connections. The goal is to better understand these co…

This study is testing a wearable sensor system to remotely monitor movement symptoms in people with Progressive Supranuclear Palsy (PSP) and related disorders. About 60 participants will wear a pendant sensor for 12 months to see if it's a practical way to track disease progressi…

This study asks 1,000 people with neurological diseases (like Alzheimer's or Parkinson's) and their caregivers to share their experiences using a head device called MemorEM. The goal is to learn how to improve the device's design and make it easier to use in future studies. No tr…