FRONTOTEMPORAL DEMENTIA

This study tests a one-time gene therapy called AVB-101 for people with a specific genetic form of frontotemporal dementia (FTD-GRN). The therapy is injected directly into the brain to restore a missing protein and potentially slow or stop the disease. 18 adults aged 30-75 with e…

This study tests a non-invasive brain stimulation method called tACS in 200 people with Alzheimer's, Lewy body dementia, or frontotemporal dementia. Participants receive either real or sham stimulation four times daily to see if it improves memory and thinking. The goal is to fin…

This study tests whether the antidepressant vortioxetine can improve mood symptoms and thinking abilities in people with early-stage behavioral variant frontotemporal dementia (bvFTD). About 50 participants will receive the drug for 12 weeks and undergo brain scans and memory tes…

This study tests a video-based program called STELLA-FTD for family members caring for a loved one with frontotemporal dementia (FTD). The program helps caregivers manage difficult behaviors and connect with support resources. Researchers will measure changes in caregiver burden …

This study uses special eye scans to look for early signs of brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will examine the tiny blood vessels and layers in the eyes of 2,000 adults—both healthy and with brain conditions—to see if eye changes c…

This study aims to create a model that better predicts how different types of dementia will progress over time. Researchers will follow 500 people with early dementia or mild cognitive impairment, using blood tests and thinking assessments. The goal is to improve prognostic confi…

This study aims to learn more about neurodegenerative disorders such as ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will screen up to 360 adults with these conditions using tests like memory exams, movement assessments, MRI scans, and genetic tes…