FRONTOTEMPORAL DEMENTIA

This study tested a drug called TPN-101 in 42 people who have ALS (Lou Gehrig's disease) or frontotemporal dementia (FTD) caused by a specific genetic change in the C9orf72 gene. The main goal was to see if the drug is safe and tolerable when taken for up to 48 weeks. Researchers…

This study tested an experimental drug called AL001 in 33 people with frontotemporal dementia caused by specific gene mutations (GRN or C9orf72). The main goals were to check safety and how the drug moves through the body. Researchers also measured changes in certain proteins in …

This study tested a dementia care program delivered by phone and web, called the Care Ecosystem, in 6 health systems across the U.S. Over 1,200 people with dementia and their caregivers took part. The program used trained navigators supervised by dementia experts to improve care …

This study tested a video-based support program for family caregivers of people with frontotemporal dementia (FTD). Sixteen caregivers participated to see if the program could reduce their stress and improve their quality of life. The goal was to help caregivers better manage cha…

This study tested a website called WeCareAdvisor that helps people caring for a loved one with dementia. The tool gives tips and strategies to manage challenging behaviors like aggression or wandering. Researchers wanted to see if it could lower caregiver stress and boost their c…

This pilot study tested whether wearable sensors can accurately measure apathy in people with frontotemporal dementia compared to healthy volunteers. Researchers used video recordings and motion sensors to track behaviors like lying, sitting, and walking in real-life settings. Th…

This study involved over 2,200 people with frontotemporal dementia (FTD) or suspected FTD. Researchers analyzed their genes to find out how often the disease is caused by inherited genetic changes. The goal was to better understand the role of genetics in FTD, not to test a treat…

This study looked at how the front part of the brain helps with reasoning and categorizing things. Researchers compared healthy volunteers to people with frontotemporal dementia or progressive supranuclear palsy. They used tasks, brain scans, and mild brain stimulation to underst…

This study examined 186 people with different types of dementia (Alzheimer's, Lewy body, frontotemporal, and corticobasal) plus healthy volunteers to see if subtle brain signs, called neurological soft signs, differ between groups. Participants took simple movement and coordinati…

This study involved telephone interviews with 26 adults who either have behavioral variant frontotemporal dementia (bvFTD) or carry a genetic risk for it. Researchers aimed to learn how the condition affects daily life, emotions, and self-perception, and what challenges people fa…

This study looked at how people with Alzheimer's disease or a type of frontotemporal dementia recall personal memories. Researchers analyzed whether memories were specific events or more general. The goal was to better understand memory loss patterns, not to test a treatment. 39 …