FOCAL EPILEPSY

This study tests the long-term safety of an experimental drug, RAP-219, in 30 adults with refractory focal epilepsy (seizures that don't respond well to current treatments). Participants must have completed a previous related study. The main goal is to check for side effects, whi…

This study tests whether a new drug, vormatrigine, can safely reduce the number of focal seizures in adults with epilepsy. About 300 participants who already take 1 to 3 seizure medications will receive either vormatrigine or a placebo. The main goal is to see if the drug lowers …

This study is testing a new drug called CB03-154 for people with focal epilepsy. It aims to see if the drug is safe and works well over a long period. The study involves 144 adults who have already completed a previous study of the same drug. Researchers will track side effects a…

This study tests an experimental drug, RAP-219, in 333 adults with focal seizures (a type of epilepsy). Participants will take the drug or a placebo for several weeks to see if it safely reduces how often seizures happen. The goal is to find a new treatment option for people whos…

This study tests a new medication, BHV-7000, for people with focal epilepsy that hasn't improved with other treatments. About 390 adults aged 18-75 will receive either the drug or a placebo to see if it safely reduces seizure frequency. The goal is to better control seizures, not…

This study tests whether the drug BHV-7000 can safely reduce seizure frequency in adults with focal epilepsy that hasn't improved with other treatments. About 390 participants will receive either one of two doses of BHV-7000 or a placebo, and researchers will compare seizure coun…

This study tests whether butylphthalide, a drug already used for stroke, can improve memory and thinking in older adults (ages 60-85) who have focal epilepsy and mild to moderate cognitive problems. About 220 participants will take either the drug or a placebo for 48 weeks while …

This early study tests whether a mild electrical current applied to the scalp (tDCS) can reduce the number and strength of seizures in people with epilepsy. About 30 adults whose seizures are not controlled by at least two medications will receive the treatment and track their se…

This study tests a new device placed under the scalp that tracks brain activity to forecast seizures in people with drug-resistant epilepsy. Researchers want to see if it's safe and can give early warnings. 12 adults with frequent seizures will wear the device and other sensors f…

This study aims to understand how the brain recognizes and remembers places, which is often impaired in people with temporal lobe epilepsy. Researchers will use a virtual tour task and brain recordings (EEG, intracranial EEG) in 620 participants, including epilepsy surgery patien…

This study will record brain activity from 30 children with drug-resistant epilepsy who are already undergoing a standard brain-mapping procedure (SEEG) to plan surgery. Researchers will place extra electrodes in three deep brain regions (thalamic nuclei) to measure how seizures …

This study is testing a new type of flexible brain electrode during epilepsy surgery. The goal is to see if these new electrodes can record brain signals as well as the standard ones. About 12 adults with focal epilepsy will have both types of electrodes placed on their brain dur…

This study aims to better understand how epileptic seizures start by recording brain activity in 50 patients with drug-resistant epilepsy who already have electrodes implanted for surgery planning. Researchers will look at individual brain cells and electrical patterns before, du…