FOCAL EPILEPSY

This study tests a new medication, BHV-7000, for people with focal epilepsy that hasn't improved with other treatments. About 390 adults aged 18-75 will receive either the drug or a placebo to see if it safely reduces seizure frequency. The goal is to better control seizures, not…

This study tests a new medicine called vormatrigine for adults with focal seizures (a type of epilepsy). About 300 people who already take 1 to 3 seizure drugs will receive either vormatrigine or a placebo. The goal is to see if vormatrigine reduces seizure frequency more than pl…

This study tests the long-term safety of an experimental drug called RAP-219 in 30 adults with refractory focal epilepsy—seizures that don't respond well to current treatments. Participants must have completed a prior RAP-219 study. The main goal is to track side effects, while a…

This study is testing the long-term safety and effectiveness of an experimental drug called CB03-154 for people with focal epilepsy. About 144 adults who completed a previous study on this drug will take it for up to a year. Researchers will track side effects and changes in seiz…

This study tests whether a drug called butylphthalide, already used for stroke, can improve thinking and memory in older adults (ages 60-85) who have both focal epilepsy and mild to moderate cognitive impairment. About 220 participants will take either the drug or a placebo for 4…

This pilot study tests whether a mild electrical current applied to the scalp (tDCS) can safely reduce the number and intensity of seizures in people with epilepsy. About 30 adults whose seizures are not controlled by at least two medications will receive the stimulation and trac…

This study tests whether BHV-7000 can safely reduce seizure frequency in adults with focal epilepsy that hasn't responded to other treatments. About 390 participants will receive either one of two doses of the drug or a placebo, and researchers will compare seizure counts over 8 …

This study looks at how the brain remembers places and scenes in people with epilepsy. Researchers will use a virtual tour task to map memory circuits in the brain. The goal is to help doctors avoid damaging memory during epilepsy surgery. About 620 adults with epilepsy and healt…

This study will record brain activity from 30 children with drug-resistant epilepsy who are already undergoing a procedure called SEEG to map their seizures. Researchers will place extra electrodes in three deep brain areas to measure how seizures spread and how these areas conne…

This study tests a new device placed under the scalp that tracks brain activity to predict seizures in people with drug-resistant epilepsy. Researchers want to see if it is safe and can give early warnings. Twelve adults with focal epilepsy will wear the device and other sensors …

This study is testing a new type of flexible brain electrode during epilepsy surgery. The goal is to see if these new electrodes can record brain signals as well as the standard ones. About 12 adults with focal epilepsy will have both types of electrodes placed on their brain dur…

This study aims to better understand how epileptic seizures start by recording brain activity in 50 patients with drug-resistant epilepsy who already have electrodes implanted for surgery planning. Researchers will look at individual brain cells and electrical patterns before, du…