Brain recording study aims to personalize epilepsy therapy for kids

NCT ID NCT06453759

Recruiting now Knowledge-focused Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will record brain activity from deep brain regions (the thalamus) in 30 children already undergoing epilepsy surgery evaluation. Researchers will place extra electrodes to measure how seizures spread and how brain areas connect. The goal is to find better targets for deep brain stimulation, which could help children whose seizures are not controlled by medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: additional electrodes placed in the thalamus during standard epilepsy monitoring
What this could lead to: If successful, this could lead to personalized deep brain stimulation targets for children with drug-resistant epilepsy, potentially improving seizure control.
What could go wrong: This is a small, early-stage observational study (30 participants) that aims to gather data, not test a treatment. It may not lead to immediate clinical benefits, and there is a small risk of bleeding from the extra electrodes.

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Conditions

The condition(s) this trial relates to.

focal epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FOCAL EPILEPSY

Contacts and locations

Locations

Great Ormond Street Hospital for Children
RECRUITING

London, WC1N 3JH, United Kingdom

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