DYSLIPIDEMIAS

This study followed adults with high cholesterol who had already completed a previous trial of the experimental drug ARO-APOC3. Participants continued receiving the medication every 3-6 months to evaluate its long-term safety and effectiveness at controlling cholesterol levels. T…

This study tested the safety and effectiveness of a new extended-release pill (K-877 ER) for lowering high triglycerides, a type of fat in the blood, over one year. It involved 121 adults with dyslipidemia who took the pill daily, with the dose adjusted if needed. The goal was to…

This study tested whether a medication called Cipros 20 could safely lower bad cholesterol (LDL) and triglycerides in adults with high cardiovascular risk. It involved 406 participants in Brazil who were randomly assigned to receive either the study drug or a comparison treatment…

This study tested if a cholesterol-lowering injection called alirocumab could reduce heart disease risk in people living with HIV. It involved 118 adults aged 40+ with well-controlled HIV and either existing heart disease or significant risk factors. Participants received either …

This large, completed Phase 3 trial tested whether a new drug called obicetrapib could help people with high cholesterol and heart disease who weren't getting enough benefit from their current medications. Over 2,500 participants took either the new pill or a placebo (a dummy pil…

This was the first study in people to test the safety of an experimental drug called ARO-ANG3, which is designed to lower unhealthy cholesterol and triglyceride levels. It involved 93 healthy volunteers and patients with high cholesterol or triglycerides. The main goal was to see…

This study tested a flexible lifestyle program for people with conditions like insulin resistance, obesity, or prediabetes. It started with either nutrition or exercise counseling. If a person's insulin resistance didn't improve enough after 8 weeks, the program could switch them…

This study tested a new, longer-acting version of an existing cholesterol medication called pemafibrate. It involved 60 adults with high triglycerides and cholesterol to see if the new pill worked as well as the standard one. Researchers compared how the body processed the drug a…

This study tested whether a new combination pill containing two drugs (obicetrapib and ezetimibe) could lower 'bad' cholesterol (LDL-C) more effectively than a placebo or either drug alone. It involved 407 adults with a genetic cholesterol disorder (HeFH) or established heart dis…

This early-stage study aimed to check if a new combination drug called Atorvo+™ is safe for people. Atorvo+™ mixes a standard cholesterol-lowering medication (atorvastatin) with CBD. Researchers gave it to 24 healthy adults for 28 days to monitor for side effects and see how the …

This study tested a new training and support program for mental health care teams. The goal was to see if this program could help providers better screen for and manage common heart disease risk factors—like high blood pressure, high cholesterol, and diabetes—in their patients wi…

This study aimed to understand if taking fish oil supplements could boost the benefits of exercise for reducing harmful inflammation linked to obesity. Researchers enrolled 129 overweight adults with prediabetes and high triglycerides. They tested whether combining fish oil with …

This was a first-in-human study to check the safety and basic effects of a single dose of an experimental drug called VSA003. It involved 36 healthy Chinese adult volunteers. The main goal was to see how the body processes the drug and to monitor for any side effects.

This study aimed to understand how taking common cholesterol-lowering drugs (statins) might change the way exercise improves fitness and muscle health. Researchers enrolled about 120 adults with high cholesterol and no heart disease, splitting them into groups that either exercis…