DYSLIPIDEMIAS

This study tests whether group medical visits (GMVs) can help patients with high cholesterol improve their health and access to care. Researchers will recruit 288 adults with dyslipidemia to attend shared appointments with a doctor and other patients, focusing on lifestyle change…

This study tests a program called PILI 'Āina to help Native Hawaiians better manage common health problems like type 2 diabetes, high blood pressure, and obesity. About 1,780 adults who are overweight and have at least one of these conditions will take part. The program focuses o…

This study tests whether nattokinase, an enzyme from fermented soy (natto), can reduce inflammation and improve heart health markers in people with high cholesterol. Researchers will give 48 adults either nattokinase or a placebo for two months and measure changes in blood marker…

This early-phase study tests whether daily consumption of milk polar lipids (a natural milk fat component) can improve cholesterol levels, reduce inflammation, and positively affect gut bacteria in adults with high cholesterol and abdominal obesity. About 130 participants will ta…

This study aims to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity by promoting traditional diets and cooking skills. About 210 adults from Hawaiian homesteads will take part in a program that includes dietary guidance, cooking demonstrations, and g…

This study tests an experimental drug called RBD5044 in 120 adults with mixed dyslipidemia, a condition where blood fats like triglycerides and cholesterol are too high. Participants will receive either the drug or a placebo twice over 12 months to see if it safely lowers triglyc…

This study tests whether a new drug (obicetrapib) alone or with another drug (evolocumab) can lower a blood fat called Lp(a) that raises heart disease risk. About 69 adults with mildly high cholesterol and elevated Lp(a) will take the drugs for 16 weeks. The goal is to see if the…

This study is testing a fixed-dose combination of two cholesterol-lowering drugs (Pitavastatin and Ezetimibe) in 10,000 adults with high cholesterol and metabolic syndrome. The goal is to see how much LDL (bad) cholesterol drops after 24 and 48 weeks of treatment in real-world se…

This study is testing a new treatment called CTX310, which uses CRISPR gene editing to turn off a gene linked to high cholesterol and fats. It is for adults aged 18 to 75 whose lipid levels remain high despite standard treatments. The goal is to see if the therapy is safe and can…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV who are on effective treatment. About 121 adults aged 40 and older with controlled HIV and at least one heart risk factor will receive …

This study looks at whether adding omega-3 (fish oil) to a common cholesterol-lowering statin can reduce plaque buildup in the carotid arteries of people with type 2 diabetes and high cholesterol. About 105 adults will be randomly assigned to receive either atorvastatin plus omeg…

This study looks at how high blood pressure, diabetes, and high cholesterol change the tiny blood vessels in the retina (the back of the eye). Researchers will use a special, non-invasive scan called OCTA to measure these changes over five years. The goal is to see if eye vessel …

This study follows 300 people having weight-loss (metabolic) surgery to see how their gut bacteria change and how that affects heart health and diabetes. Researchers collect stool, blood, and tissue samples before and up to 3 years after surgery. The goal is to learn which gut mi…

This study looks at the diet, heart health, body composition, and mental well-being of 600 U.S. Army soldiers. Researchers will collect information through surveys, physical tests, and blood samples. The goal is to understand how nutrition and health affect soldier performance an…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and checking for conditions like diabetes, high blood pressure,…

This study is enrolling 20,000 adults in Taining County, China, to better understand chronic diseases like high blood pressure, diabetes, and frailty. Researchers will collect health data and samples over three years to find patterns and risk factors. The goal is to create a bett…

This study is following 2,500 adults in Puerto Rico, ages 30 to 75, to learn how stress, diet, and living environment affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years. The goal is to gui…

This study is following 1,000 people who are having bariatric (weight-loss) surgery to see how their weight, body fat, and blood sugar levels change over two years. Participants will have tests before surgery and at several follow-up visits. The goal is to better understand the h…

This study tests whether a computer alert system can help doctors remember to prescribe cholesterol-lowering medications to people with peripheral artery disease (PAD) who aren't currently taking them. About 400 adults with PAD will take part. The goal is to see if the alerts lea…

This study looks at whether cholesterol tests taken during a heart attack hospital stay give reliable results. About 100 adults admitted for a heart attack will have their cholesterol checked at the start, two days later, and again 4-6 weeks after leaving the hospital. The goal i…