Dyslipidemia

This study tests whether a cookie made from Golden Rice and red betel leaf can improve cholesterol and triglyceride levels in adults with type 2 diabetes. Over 28 days, 102 participants will eat the cookies daily, and their blood fat levels will be measured before and after. The …

This study tests whether adding ear acupressure (small pellets on specific ear points) to the standard cholesterol drug atorvastatin can lower blood fats and improve phlegm-dampness symptoms better than a sham ear treatment plus atorvastatin. Eighty adults with dyslipidemia and p…

Researchers are testing a new oral drug called AZD0780 in healthy adults, some with high LDL cholesterol. The Phase 1 trial gives single and multiple rising doses to check safety, side effects, and how the body processes the drug. About 183 volunteers will take either AZD0780 or …

This study looks at whether taking two approved medicines together—escitalopram for depression and atorvastatin for high cholesterol—can improve both mood and blood fat levels in adults. Participants are adults diagnosed with both a depressive episode and mild-to-moderate dyslipi…

This study tests whether taking date cider vinegar daily, alone or combined with 5:2 intermittent fasting, can improve cholesterol and other metabolic measures in adults with prediabetes and mild to moderate high cholesterol or blood pressure. Participants are randomly assigned t…

This early-stage trial tests two experimental drugs, UI111 and UIC202006, in healthy adult volunteers. The goal is to check the drugs' safety and how the body processes them after a single dose taken with food. The study uses a crossover design, meaning each participant receives …

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study tested whether bars made with polyunsaturated fatty acids could improve cholesterol and fat levels in people with metabolic syndrome. 60 adults aged 40-65 with high BMI and abnormal cholesterol took part. The goal was to see if these bars could help control dyslipidemi…

This study looked at whether bread made from watermelon rind could improve heart health in 120 adults with mild to moderate heart issues. Participants were between 35 and 65 years old and had conditions like high blood pressure, unhealthy cholesterol levels, or pre-diabetes. The …

This early-stage study tested an experimental drug called ALN-APOC3 in 32 adults with dyslipidemia (abnormal blood fat levels). The main goal was to check safety and how the drug affects fat levels in the blood. Participants were otherwise healthy and either not on statins or on …

This study tested whether eating tuna-based nuggets for three months could improve health in 120 people with heart disease and related conditions like obesity and diabetes. The nuggets were given as a source of selenium. Results showed improvements in some markers of inflammation…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This Phase 3 trial tested MCI-196, a drug that binds phosphorus and lowers cholesterol, in 642 adults on dialysis with chronic kidney disease. Participants received either MCI-196 or a placebo for 12 weeks. The goal was to see if the drug could safely reduce both serum phosphorus…

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study tested whether a Mediterranean diet that removes red and processed meat can lower LDL cholesterol and other heart disease risk factors. 157 adults with high cholesterol were assigned to either the special diet or standard heart-health advice for 8 weeks. Researchers me…

This study tested whether a daily combination of commercially available food supplements could help overweight adults over 45 feel fuller and improve their cholesterol and blood sugar levels. Eighty participants were split into two groups: one took the supplement mix for 12 weeks…

This Phase 3 trial tested a new combination drug called Cipros 10 against the standard statin Crestor in 146 adults with dyslipidemia (high cholesterol and triglycerides). The goal was to see if Cipros 10 could lower triglyceride levels more effectively. Participants took one pil…

This study tested a new daily medication called AZD0780 in 428 adults with dyslipidemia (abnormal cholesterol levels). Participants took one of several doses of AZD0780 or a placebo for 12 weeks. The main goal was to see how much the drug lowered LDL (bad) cholesterol compared to…

This early-stage study tested a new drug called AZD0780 in 81 healthy adults with high cholesterol. Participants received AZD0780 alongside other cholesterol-lowering medicines like ezetimibe, rosuvastatin, or bempedoic acid. The goal was to see how well the combination lowers LD…

This study tested a 3-month lifestyle program, delivered by Pasifika community health workers, to help Native Hawaiians and Pacific Islanders with conditions like diabetes, high blood pressure, and obesity. The program included healthy eating and activity tips plus support for so…

This completed Phase 3 trial tested a combination of two drugs, JW0108 and C2407, in 145 adults with high cholesterol (dyslipidemia). The goal was to see if the combo lowers LDL ('bad') cholesterol more effectively and safely than placebo. Researchers measured changes in LDL leve…

This pilot trial tests whether a multi-part program given to emergency department patients with metabolic syndrome can encourage more walking and healthier habits. Participants receive a Fitbit, watch a short educational video, get a written exercise prescription, receive text re…

Researchers are testing whether nicotinamide riboside, a form of vitamin B3 sold as a supplement, can reduce immune system activation in people with mild to moderate psoriasis. The trial enrolls adults aged 18 to 80 who are not on biologic therapy. Participants take either the su…

Researchers are studying how traditional and non-traditional heart risk factors relate to cholesterol levels in hospitalized Mexican adults. The study focuses on HDL cholesterol, often called good cholesterol, and how it behaves in people who smoke or have certain dietary habits.…

This study checks if a new version of a cholesterol-lowering drug (AJU-C715) works the same as the original (C715R) in 60 healthy adults aged 19-59. Participants take a single dose of each drug in random order and have blood tests to compare drug levels. The goal is to see if the…

This study looked at how fat-carrying particles called lipoproteins work in healthy people and those with high cholesterol or other lipid disorders. Researchers injected tiny, safe amounts of radioactive lipoproteins to track them in the body. The goal was to better understand ho…

This study aimed to find new gene changes that cause rare lipid disorders. Researchers used advanced genetic testing to look at many genes at once in 140 people and their relatives. The goal was to discover causes that older methods missed.

This study looks at whether adults aged 70 and older with multiple chronic conditions (but no heart disease) can safely stop taking statins. Researchers are comparing those who continue statins to those who stop, tracking deaths and major heart events over 2-4 years. The goal is …

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This early-stage trial tests a new drug called AJU-C716 against a reference drug (C716R) in 41 healthy adults aged 19 to 55. The goal is to see how safe the drug is and how the body processes it. This study does not test if the drug works for high cholesterol—it only looks at saf…

This study looked at 99 people with high heart risk to understand how a protein called CETP affects plaque buildup in arteries. Researchers measured CETP activity, artery thickness, and calcium scores. The goal was to learn more about heart disease, not to test a new treatment.

This early-stage study tested a single injection of HRS-5632 in 50 healthy adults to check its safety and how the body processes it. Participants were aged 18 to 55 and in good health. The study did not aim to treat any disease, only to gather initial safety information.

This completed study examined blood samples from 40 adults to see if high levels of lipoprotein (a), a type of cholesterol, are linked to fewer or different blood vessel repair cells. Participants with high Lp(a) were compared to those with normal levels. The goal was to better u…