Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

STREAM trial: should seniors ditch statins?

NCT ID NCT05178420

Knowledge-focused Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study looks at whether adults aged 70 and older with multiple chronic conditions (but no heart disease) can safely stop taking statins. Researchers are comparing those who continue statins to those who stop, tracking deaths and major heart events over 2-4 years. The goal is to provide clear guidance on when it's safe to discontinue statins in this population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,880 people

The number who actually took part.

Started

Nov 2021

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

70 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Written informed consent * ≥70 years of age * Multimorbid with ≥2 coexistent chronic conditions (defined by ICD-10 codes) with an estimated duration of 6 months or more based on clinical decision, besides dyslipidemia treated by statins * Intake of a statin for ≥80% of the time during the year before enrollment Exclusion Criteria: 1. Cardiovascular secondary prevention setting based on previous large statin trials, defined as: * History of myocardial infarction type 1 (NSTEMI/STEMI), OR * History of unstable angina, defined as ACS symptomatic at rest, crescendo or new-onset angina (CCS 2 or 3) without ECG or cardiac biomarker changes (based on available documents), OR * Stable angina pectoris with a documented ischemia on a stress test or with a significant coronary disease defined as a coronary stenosis \>50%, OR * History of percutaneous coronary intervention (balloon or stent) or coronary artery bypass graft, OR * History of Stroke (does not apply to clearly cardio-embolic causes for stroke e.g. due to atrial fibrillation), OR * History of Transient Ischemic Attack, defined as transient neurological deficit without diffusion restriction in MRI, OR * History of carotid revascularization (stent, bypass, CEA (carotid thrombendartectomy)), OR * History of peripheral arterial disease requiring revascularization (e.g. PTA (percutaneous transluminal angioplasty), stent, femoral TEA (thrombendartectomy), bypass; Fontaine IV) 2. Aortic disease that required a vascular repair or aortic aneurysm with a maximum diameter \>5.5 cm (men) or \>5.2 cm (women) based on available documents 3. Diagnosis of familial hypercholesterolemia based on Dutch lipid score ≥6 based on available documents (LDL cholesterol, family history, personal history) 4. Elevated risk of death within 3 months after baseline, defined as: * Hospitalized patients planned for palliative care within 24h of admission OR * Hospitalized patients with a Palliative Performance Scale (PPS) level \<30% (based on situation at least 1 month before hospitalization), this corresponds to an estimated survival of 43% after 3 months; OR * Patients with an advanced metastatic cancer prognosis of ≤20% survival rate within 1 year after baseline (based on: https://cancersurvivalrates.com) 5. Participation to a clinical trial with potential impact on the STREAM cardiovascular endpoints (based on clinical judgment)

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Dyslipidemia are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

inherited lipid metabolism disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Statin treatment for primary prevention

Contacts and locations

Locations

  • CHUV Lausanne

    Lausanne, Switzerland

  • Centre hospitalier Bienne

    Biel/Bienne, Canton of Bern, 2501, Switzerland

  • Clinic for General Internal Medicine, Bern University Hospital Bern

    Bern, 3010, Switzerland

  • HFR Fribourg

    Fribourg, 1752, Switzerland

  • Hospital Burgdorf

    Burgdorf, Switzerland

  • Hospital Langnau

    Langnau, Switzerland

  • Hospital St. Gallen (Geriatrics)

    Sankt Gallen, Switzerland

  • Hôpital La Tour

    Geneva, Switzerland

  • Hôpital Neuchâtelois

    Neuchâtel, Switzerland

  • Hôpitaux Universitaires de Genève (Geriatrics)

    Geneva, Switzerland

  • Hôpitaux Universitaires de Genève (Internal Medicine)

    Geneva, Switzerland

  • Kantonsspital Aarau

    Aarau, Switzerland

  • Kantonsspital Baden

    Baden, Switzerland

  • Kantonsspital Graubünden

    Chur, Kanton Graubünden, 7000, Switzerland

  • Kantonsspital Schaffhausen

    Schaffhausen, 8208, Switzerland

  • Klinik Barmelweid AG

    Barmelweid, Canton of Aargau, 5017, Switzerland

  • Leids Universitair Medisch Centrum

    Leiden, South Holland, 2333, Netherlands

  • Luzerner Höhenklinik Montana AG

    Crans-Montana, Valais, 3963, Switzerland

  • Ospedale Regionale di Bellinzona e Valli

    Bellinzona, Switzerland

  • Spital Limmattal

    Schlieren, Canton of Zurich, 8952, Switzerland

  • Stadspital Waid

    Zurich, Switzerland

  • Stadtspital Triemli

    Zurich, Switzerland

  • UNIVERSITY HOSPITAL CENTER of Bordeaux

    Bordeaux, Nouvelle Acquitaine, 33404 Talence Cedex, France

  • Universitätsspital Basel

    Basel, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.