DIARRHEA

This study tests a new vaccine called IVT Shigella-04 in 60 healthy adults aged 18 to 49. The goal is to see if it is safe and helps the body build defenses against Shigella bacteria, which causes severe diarrhea. Participants will receive two shots and be monitored for side effe…

This study looks at whether adding the medicine rifaximin to standard oral rehydration therapy helps children aged 6 to 11 with bacterial diarrhea get better faster. About 54 children will either receive rifaximin plus rehydration or rehydration alone for 3 days. Researchers will…

This study tests whether adding milk proteins (lactoferrin and lysozyme) to the diet of malnourished children aged 6-24 months can prevent severe diarrhea and help them regain strength. Six hundred children in Kenya will receive daily supplements for 6 months after hospital disch…

This study tests whether a 7-day water, sanitation, and hygiene program can reduce new cholera infections in neighborhoods where someone already has cholera. About 3,140 people living near a cholera patient will receive the program. The goal is to see if this approach helps stop …

This early-phase study at Mayo Clinic tests whether adding the medication mirtazapine to a low-FODMAP diet works better than diet alone for easing IBS with diarrhea. About 20 adults aged 18-70 with moderate-to-severe symptoms will join. The goal is to see if the combo improves pa…

This early-phase study tests whether fecal microbiota transplantation (FMT) can safely reduce diarrhea and colon inflammation caused by immune-checkpoint inhibitors in people with genitourinary and other cancers. About 40 participants will receive FMT and be monitored for side ef…

This study tests whether a fecal transplant from a carefully selected donor can reduce symptoms in people with moderate to severe irritable bowel syndrome (IBS) who have diarrhea. The donor stool has low levels of certain proteins and contains a specific bacteria. The main goal i…

This study tests an investigational drug called brenipatide for adults with irritable bowel syndrome with diarrhea (IBS-D). About 531 participants will receive either the drug or a placebo as a shot under the skin. The goal is to see if it safely reduces daily abdominal pain and …

This study tests if fecal microbiota transplantation (FMT) can help people with diarrhea and colitis caused by immune checkpoint inhibitors, a type of cancer immunotherapy. About 20 adults with melanoma or kidney cancer will receive either FMT capsules or placebo capsules alongsi…

This early-phase study tests a live bacterial treatment called SER-155 for people who develop diarrhea and colon inflammation from cancer immunotherapy. The goal is to see if it is safe and can reduce symptoms without needing strong immune-suppressing drugs. About 15 adults will …

This study follows 30 adults who had their colon removed and their small intestine connected to the rectum. Researchers will track symptoms like diarrhea, urgency, and incontinence, and how these affect quality of life. The goal is to better understand and manage this condition, …

This study looks at why some people with alpha-gal syndrome (a meat allergy) get stomach pain, diarrhea, nausea, or vomiting after eating red meat. Researchers will give 30 adults pork with and without the allergy-triggering substance to see what happens inside their bodies. The …