DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Clinical trials for DEPRESSIVE DISORDER, TREATMENT-RESISTANT explained in plain language.
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New nasal spray could help those with stubborn depression
Disease control Recruiting nowThis study tests esketamine nasal spray in 47 Korean adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants will use the spray themselves twice a week for 4 weeks. The main goal is to see if depressive symptoms improve, me…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE4 • Sponsor: Janssen Korea, Ltd., Korea • Aim: Disease control
Last updated Jun 23, 2026 12:09 UTC
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New hope for tough depression: which brain zaps work best?
Symptom relief Recruiting nowThis study tests two types of magnetic brain stimulation (rTMS and deep TMS) to see which works better for people with depression that hasn't responded to medication. About 152 adults will receive 20 sessions over 4 weeks, plus standard care. Researchers will track mood changes f…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: Centre Hospitalier Henri Laborit • Aim: Symptom relief
Last updated Jun 22, 2026 12:06 UTC
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Can faster brain zaps beat depression in seniors?
Symptom relief Recruiting nowThis study tests whether giving multiple sessions of magnetic brain stimulation each day works better than the usual one-session-per-day approach for treating depression in people aged 60 and older. About 280 participants will receive active treatment, with some getting the accel…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Symptom relief
Last updated Jun 22, 2026 11:59 UTC
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Texts and brain zaps: new combo for tough depression?
Symptom relief Recruiting nowThis study tests whether adding a supportive text-messaging program (Text4Support) to repetitive transcranial magnetic stimulation (rTMS) improves depression symptoms more than rTMS alone. About 200 adults with treatment-resistant depression will be randomly assigned to one of tw…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: NA • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 22, 2026 11:54 UTC
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New hope for tough depression? drug trial targets Non-Responders
Symptom relief Recruiting nowThis study tests a new medicine called ACP-211 in adults with major depression who haven't gotten better with standard antidepressants. About 153 people will receive either the drug or a placebo for 28 days. The main goal is to see if ACP-211 reduces depression symptoms more than…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: ACADIA Pharmaceuticals Inc. • Aim: Symptom relief
Last updated Jun 17, 2026 12:09 UTC
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New hope for Treatment-Resistant depression: Fast-Acting drug trial launches
Symptom relief Recruiting nowThis study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: National Institute of Mental Health (NIMH) • Aim: Symptom relief
Last updated Jun 15, 2026 19:04 UTC
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Ketamine's brain secrets: new study targets Depression's root
Knowledge-focused Recruiting nowThis study looks at how a single dose of ketamine affects key brain chemicals (GABA and glutamate) in 30 adults with treatment-resistant depression. Half receive ketamine, half a placebo, while brain scans and blood tests track chemical changes. The goal is to understand why keta…
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE2 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 23, 2026 11:58 UTC
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Laughing gas scans could unlock depression secrets
Knowledge-focused Recruiting nowThis study looks at how nitrous oxide (laughing gas) changes brain connections in people with hard-to-treat depression compared to healthy volunteers. About 50 participants will get either the gas or a placebo and have their brains scanned with MRI. The goal is to understand how …
Matched conditions: DEPRESSIVE DISORDER, TREATMENT-RESISTANT
Phase: PHASE1 • Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 11, 2026 12:09 UTC