New nasal spray could help those with stubborn depression
NCT ID NCT07053345
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 35 times
Summary
This study tests esketamine nasal spray in 47 Korean adults with treatment-resistant depression (depression that hasn't improved with other treatments). Participants will use the spray themselves twice a week for 4 weeks. The main goal is to see if depressive symptoms improve, measured by a standard depression scale.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Asan Medical Center
RECRUITINGSeoul, 05505, South Korea
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Cha Ilsan Medical Center
RECRUITINGGoyang Si Gyeonggi Do, 10414, South Korea
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Kangbuk Samsung Hospital
RECRUITINGSeoul, 03181, South Korea
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Kyung Hee University Hospital
RECRUITINGSeoul, 130 050, South Korea
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Samsung Medical Center
RECRUITINGSeoul, 06351, South Korea
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Wonkwang University Hospital
RECRUITINGIksan, 570 711, South Korea
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
esketamine nasal spray
What this could lead to
If it works, this could offer a new option for people with depression that hasn't improved with other treatments.
What could go wrong
This is a small, early-phase study with only 47 participants, so results may not apply to everyone. Esketamine can cause side effects like dizziness, nausea, or dissociation.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.